人IMP脱氢酶-猫眼课题宝

人IMP脱氢酶

批准号：

6586632

负责人：

JOHN R SOMOZA

金额：

$14.32万

依托单位：

STANFORD UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2002

资助国家：

美国

项目状态：

已结题

起止时间：

2002-03-01 至 2003-02-28

来源：

https://reporter.nih.gov/project-details/6586632

关键词：

bioimaging /biomedical imaging biomaterials biomedical resource genome radiography structural biology

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英文摘要

Human IMP dehydrogenase (IMPDH) catalyzes the NAD-dependent oxidation of IMP to XMP, making it a key component in the synthesis of guanine nucleotides. Two isoforms of the enzyme exit and these two forms share approximately 84% sequence identity. There is evidence that inhibitors of type II IMPDH are effective antiproliferative agents, and may be useful in controlling some forms on cancer. It has also been shown that inhibitors if IMPDH have immunosuppressive activity. Future efforts to understand and utilize the therapeutic benefits resulting from the inhibition of IMPDH activity would be greatly aided by obtaining the structure of this enzyme.

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