HUMAN IMP DEHYDROGENASE

人IMP脱氢酶

• 批准号: 6586632
• 负责人: JOHN R SOMOZA
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586632
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; genome; radiography; structural biology

Human IMP dehydrogenase (IMPDH) catalyzes the NAD-dependent oxidation of IMP to XMP, making it a key component in the synthesis of guanine nucleotides. Two isoforms of the enzyme exit and these two forms share approximately 84% sequence identity. There is evidence that inhibitors of type II IMPDH are effective antiproliferative agents, and may be useful in controlling some forms on cancer. It has also been shown that inhibitors if IMPDH have immunosuppressive activity. Future efforts to understand and utilize the therapeutic benefits resulting from the inhibition of IMPDH activity would be greatly aided by obtaining the structure of this enzyme.

人IMP脱氢酶（IMPDH）催化nadd依赖性