Mississippi Functional Genomics Network

密西西比功能基因组网络

• 批准号: 6413312
• 负责人: GEORGE M SANTANGELO
• 金额: $ 199.65万
• 依托单位: UNIVERSITY OF SOUTHERN MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-20 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6413312
• 关键词: functional /structural genomics; proteomics

DESCRIPTION (provided by applicant): Modern biological research is moving towards the examination of large-scale systems. Many advances can be cited to exemplify this trend, including high-throughput DNA sequencing, analysis of gene expression patterns, and drug discovery strategies. Other high-throughput applications involve direct analysis of proteins to characterize their structural modification, cellular localization, or effect on cell morphology. These new technologies are described by the umbrella term "Functional Genomics." Without the networked, high-throughput instrumentation that permits accumulation and bioinformatics-driven analysis of the associated large-scale data sets, competitive biomedical research in the State of Mississippi will soon become difficult, if not impossible. More importantly, the capacity to train talented undergraduate and graduate students for productive careers in biomedical research will decline precipitously. Therefore, it is proposed to establish a BRIN in Mississippi, which will generate an invaluable training pipeline of investigators needed for the modern biomedical research workforce. A critical facet of this Network involves strengthening the basic science departments of undergraduate institutions, most notably the HBCUs in Mississippi. This will include research and training opportunities for HBCU faculty and students to gain hands-on experience with the equipment and methodologies that will dominate the biomedical sciences for years to come. The new Genomics, Cellomics, Imaging, Proteomics, and Pharmacogenetics Facilities will thus help to establish a modern workforce of biomedical investigators helping to correct the dramatic under-representation of minorities in health-related fields of research.

描述（由申请人提供）：现代生物学研究正在不断发展 面向大型系统的检查。许多进步可以被引用 体现了这一趋势，包括高通量 DNA 测序、分析 基因表达模式和药物发现策略。其他高通量 应用涉及蛋白质的直接分析以表征 它们的结构修饰、细胞定位或对细胞的影响 形态学。这些新技术由总括术语描述 “功能基因组学。”没有联网的高通量仪器 允许对相关的积累和生物信息学驱动的分析 大规模数据集、有竞争力的生物医学研究 密西西比州很快就会变得困难，甚至不可能。更重要的是， 培养优秀本科生和研究生的能力 生物医学研究领域的生产性职业将急剧下降。 因此，建议在密西西比州建立 BRIN，这将 为研究人员建立宝贵的培训渠道 现代生物医学研究队伍。该网络的一个关键方面 涉及加强本科生基础科学部门 机构，尤其是密西西比州的 HBCU。这将包括 HBCU 教师和学生获得研究和培训机会 将主导设备和方法的实践经验 未来几年的生物医学科学。新的基因组学、细胞组学、 因此，成像、蛋白质组学和药物遗传学设施将有助于 建立一支现代化的生物医学研究人员队伍，帮助纠正 少数群体在健康相关领域的代表性严重不足 研究。