Mississippi Functional Genomics Network

描述(申请人提供)：现代生物学研究令人感动 向大规模系统的检查迈进。许多进步可以被引用来 例证这一趋势，包括高通量DNA测序，分析 基因表达模式和药物发现策略。其他高吞吐量 应用包括直接分析蛋白质以表征 它们的结构修饰、细胞定位或对细胞的影响 形态学。这些新技术用总括术语来描述 “功能基因组学”如果没有联网、高吞吐量的仪器 它允许积累和生物信息学驱动的相关分析 大规模数据集，竞争激烈的生物医学研究 密西西比州将很快变得困难，如果不是不可能的话。更重要的是， 培养高素质本科生和研究生的能力 生物医学研究中富有成效的职业将急剧下降。 因此，建议在密西西比州设立一个布林，它将 产生一条宝贵的调查人员培训渠道，以满足 现代生物医学研究队伍。此网络的一个关键方面 涉及加强本科生基础科学系建设 机构，最著名的是密西西比州的HBCU。这将包括 为HBCU教职员工和学生提供研究和培训机会 拥有主导设备和方法的实践经验 未来几年的生物医学科学。新的基因组学，细胞组学， 因此，成像、蛋白质组学和药物遗传学设施将有助于 建立一支现代化的生物医学调查人员队伍，帮助纠正 少数群体在与健康有关的领域的代表性严重不足 研究。

DESCRIPTION (provided by applicant): Modern biological research is moving towards the examination of large-scale systems. Many advances can be cited to exemplify this trend, including high-throughput DNA sequencing, analysis of gene expression patterns, and drug discovery strategies. Other high-throughput applications involve direct analysis of proteins to characterize their structural modification, cellular localization, or effect on cell morphology. These new technologies are described by the umbrella term "Functional Genomics." Without the networked, high-throughput instrumentation that permits accumulation and bioinformatics-driven analysis of the associated large-scale data sets, competitive biomedical research in the State of Mississippi will soon become difficult, if not impossible. More importantly, the capacity to train talented undergraduate and graduate students for productive careers in biomedical research will decline precipitously. Therefore, it is proposed to establish a BRIN in Mississippi, which will generate an invaluable training pipeline of investigators needed for the modern biomedical research workforce. A critical facet of this Network involves strengthening the basic science departments of undergraduate institutions, most notably the HBCUs in Mississippi. This will include research and training opportunities for HBCU faculty and students to gain hands-on experience with the equipment and methodologies that will dominate the biomedical sciences for years to come. The new Genomics, Cellomics, Imaging, Proteomics, and Pharmacogenetics Facilities will thus help to establish a modern workforce of biomedical investigators helping to correct the dramatic under-representation of minorities in health-related fields of research.