Mississippi Functional Genomics Network

描述（由申请人提供）：现代生物学研究正在发展 对大规模系统的研究。许多进步可以被引用， 顺应这一趋势，包括高通量DNA测序， 基因表达模式和药物发现策略。其他高通量 这些应用涉及直接分析蛋白质以表征 它们的结构修饰、细胞定位或对细胞的影响 形态学这些新技术被概括为 功能基因组学“如果没有联网的高通量仪器 允许积累和生物信息学驱动的相关分析， 大规模的数据集，竞争力的生物医学研究在国家的 密西西比很快就会变得困难，如果不是不可能的话。更重要的是， 培养优秀本科生和研究生的能力， 生物医学研究的生产性职业将急剧下降。 因此，建议在密西西比建立BRIN， 建立一个宝贵的调查人员培训渠道， 现代生物医学研究人员。该网络的一个重要方面是 包括加强本科生的基础科学部门 机构，特别是密西西比的HBCUs。这将包括 研究和培训机会HBCU教师和学生获得 具有将占主导地位的设备和方法的实践经验 生物医学科学的未来。新的基因组学，细胞组学， 因此，成像、蛋白质组学和药物遗传学设施将有助于 建立一支现代化的生物医学研究人员队伍，帮助纠正 少数群体在卫生相关领域的代表性严重不足， research.

DESCRIPTION (provided by applicant): Modern biological research is moving towards the examination of large-scale systems. Many advances can be cited to exemplify this trend, including high-throughput DNA sequencing, analysis of gene expression patterns, and drug discovery strategies. Other high-throughput applications involve direct analysis of proteins to characterize their structural modification, cellular localization, or effect on cell morphology. These new technologies are described by the umbrella term "Functional Genomics." Without the networked, high-throughput instrumentation that permits accumulation and bioinformatics-driven analysis of the associated large-scale data sets, competitive biomedical research in the State of Mississippi will soon become difficult, if not impossible. More importantly, the capacity to train talented undergraduate and graduate students for productive careers in biomedical research will decline precipitously. Therefore, it is proposed to establish a BRIN in Mississippi, which will generate an invaluable training pipeline of investigators needed for the modern biomedical research workforce. A critical facet of this Network involves strengthening the basic science departments of undergraduate institutions, most notably the HBCUs in Mississippi. This will include research and training opportunities for HBCU faculty and students to gain hands-on experience with the equipment and methodologies that will dominate the biomedical sciences for years to come. The new Genomics, Cellomics, Imaging, Proteomics, and Pharmacogenetics Facilities will thus help to establish a modern workforce of biomedical investigators helping to correct the dramatic under-representation of minorities in health-related fields of research.