MS INBRE UMMC: GENOMICS FACILITY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。UMC的基因组学设施是一个培训设施，提供使用通常但不完全与微阵列技术相关的专用设备的机会。基因组学设施的使用率很稳定。目前使用的最活跃的设备是Agilent生物分析仪（用于DNA和RNA分析）、ScanArray Express扫描仪（微阵列分析）和毗邻的分析计算机和程序。整个医疗中心的许多实验室定期利用该设施。该设施还扫描幻灯片，为其他实验室在国家内，不是在地铁杰克逊地区。目前我们正在为拉里汉森博士扫描鲶鱼微阵列他在密西西比州立大学的实验室工作。我们将继续引进和培训新的微阵列技术实验室。虽然去年有几个设施使用者申请赠款，但没有收到任何赠款。然而，我们将继续与其他几个实验室进行可行性研究，我们希望这些研究能成为可资助的提案。一项研究酒精对斑马鱼表观遗传影响的提案将在目前的资助期内提交。我们还同意对多伦多大学健康科学网络和W. L.戈尔事务所此外，我们继续向病理学住院医师展示如何标记RNA，杂交和分析。Warren May博士是预防医学系的生物统计学家，他与大多数通过该设施进行微阵列分析的小组合作。我们要求所有想要使用该设施的小组在开始之前与他协商他们的实验设计。我们也鼓励用户咨询和合作，邓友平博士是南密西西比大学的生物信息学专家，也是MFGN生物信息学分支的联合主任。这是该设施的目标，以帮助促进研究和生命科学培训的质量和数量在密西西比州内通过提供给所有学生和教师的研究人员在状态的增强;培训他们的方法和使用的所有设备内的设施，为他们的研究。该设施由主任和设施经理监督，几乎随时可供所有用户使用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Genomics Facility at UMC is a training facility that provides access to specialized equipment typically, but not entirely, associated with microarray technology. The genomics facility is seeing steady usage. The most active pieces of equipment being used are the Agilent bioanalyzer (for DNA and RNA analyses), the ScanArray Express scanner (microarray analysis) and the adjoining analytical computer and programs. Numerous labs throughout the Medical Center avail themselves of the facility on a regular basis. The facility also scans slides for other labs within the state that are not in the metro Jackson area. Presently, we are scanning catfish microarrays for Dr. Larry Hansen?s lab at Mississippi State University. We continue to introduce and train new labs in microarray technology. Although several facility users applied for grants this past year none were received. However we continue to do feasibility studies with several other labs which we hope can be garnered into fundable proposals. A proposal to study epigenetic effects of alcohol on zebrafish will be submitted within the current funding period. We have also agreed to beta-test some microarrays made by the University of Toronto Health Science network and W.L. Gore and Associates. Additionally we continue to demonstrate to pathology residents how RNA is labeled, hybridized and analyzed. Dr. Warren May, a Biostatistician in the Department of Preventive Medicine works with most of the groups doing microarray analysis through the facility. We require all groups wanting to use the facility to consult with him about the design of their experiments before beginning. Users are also encouraged to consult and collaborate with Dr. Youping Deng who is the bioinformatics expert at the University of Southern Mississippi and co-director of the bioinformatics branch of the MFGN. It is the goal of this facility to help facilitate the enhancement of the quality and quantity of research and life science training within the state of Mississippi through being available to all student and faculty researchers within the state; to train them in the methods and use of all of the equipment within the facility for their research. The facility is supervised by the director and facility manager and is available to all users at virtually anytime.