STRUCTURE & FUNCTION OF BOMBESIN LIKE PEPTIDES

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To date, two mammalian bombesin-like peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB), have been characterized. These two peptides are widely distributed in mammalian nervous system and GI tract; but, of greatest clinical importance, GRP is expressed by many neoplasms and may stimulate the growth of these neoplasms. Recent studies suggest that there are a number of additional bombesin-like peptides that are yet to be identified and that these peptides likely play an important role in growth and development. Thus, we are attempting to identify new bombesin-like peptides by cross-hybridization with cDNAs encoding previously characterized bombesin-like peptides, as well as by using antibodies to amphibian bombesin-like peptides. Once new bombesin-like peptides are discovered, distribution studies and physiologic studies using the primate model will be established to determine the role of these new peptides in normal and neoplastic processes. To date , we have discovered 3 new amphibian bombesin-like peptides and two new amphibian bombesin receptors. Our new data suggests that the ligand for recently described bombesin BRS-3 receptor may turn out to be the long sought mammalian bombesin. FUNDING NIH CA39237 PUBLICATIONS Pradhan TK, Katsuno T, Ryan RR, Mantey SA, Akeson MA, Donohue PJ, Battey JF, Spindel ER. The bombesin receptor subtype 4 is coupled to phospholipase C and has a unique pharmacology. In Meeting of the American Gastroenterology Society (held in New Orleans, LA, May 16-20, 1998 (abstract).