Core--Methodology /Biostatistics

描述（摘自研究者摘要）：密歇根社会不平等、心理和身体跨学科研究中心（MICSIMB）将培养一个跨学科研究项目，旨在了解心理社会状态（信仰、态度、情感状态、价值观和社会关系）、它们的决定因素、压力和压力的病理生理标志，在身心障碍的发展、儿童发展和衰老方面的相互作用。调查人员将重点放在健康方面的社会经济和种族不平等，以及基于社区的儿童和成人、男性和女性以及少数民族样本的生命历程和社区决定因素上。这些项目代表了新颖的、具有成本效益的、相互关联的调查：(1)儿童的身体、情感和认知状况在多大程度上反映了父母的社会经济地位、收入轨迹、经济压力和社区特征的影响；(2)糖皮质激素和血清素机制在心理社会状态、社会经济地位和心血管疾病过度风险之间的关联中的作用；(3)利用最先进的社区因素评估技术，在一个多层次代表性社区样本中，研究了一系列广泛的心理属性、它们的前因和健康后遗症，以及相关的压力生物标志物之间的相互关系；(4)利用50多年的评估数据，研究了不同生命阶段的社会经济、生物和心理社会因素对心理社会健康、心血管危险因素、成年期亚临床和诊断心血管疾病的广泛指标的贡献；(5)长期经济压力对一组随机选择的有年幼孩子的贫困妇女的健康和功能的影响，作为福利改革的一部分，这些妇女从密歇根州的AFDC角色转移到新的“工作福利”计划中。新方法和生物统计工具的开发和利用、职业发展和传播活动，加上上述研究计划，将有助于进一步将MICSIMB建立为身心相互作用、身心健康、心血管疾病、老龄化和儿童发展研究的主要国际中心。这将由来自9个学科的21名经验丰富的研究人员组成的团队完成，他们将以共生的方式聚集在一起，开展5个研究项目，并努力扩大可用于此类分析的方法和生物统计工具。

DESCRIPTION (adapted from investigator's abstract): The Michigan Interdisciplinary Center on Social Inequalities, Mind, and Body (MICSIMB), will foster an interdisciplinary research program seeking to understand the interactions of psychosocial states (beliefs, attitudes, affective states, values, and social relationships), their determinants, stress, and pathophysiologic marker of stress, in the development of physical and mental disorders, in child development, and in aging. The investigators include a focus on socioeconomic and racial inequalities in health, and on lifecourse and community determinants in community-based samples of children and adults, men and women, and minorities. The projects represent novel, cost-effective, and interrelated investigations of: (1) the extent to which children's physical, emotional, and cognitive status reflect the influence of parental socioeconomic status, income trajectories economic stress, and community characteristics; (2) the role of glucocorticoid and serotonergic mechanisms in the associations between psychosocial states, SES, and excess risk for CVD; (3) the interrelations between a broad array of psychological attributes, their antecedents and health sequelae, and related biological markers of stress, within a multilevel representative community sample, utilizing state of the art assessment of community factors; (4) contributions of socioeconomic, biological, and psychosocial factors at different stages of the life course to a broad range of indicators of psychosocial well-being, cardiovascular risk factors, subclinical and diagnosed CVD in adulthood, using data reflecting over 50 years of assessments; and, (5) the impact of chronic economic stress, in situ, on health and function in a randomly selected cohort of poor women with young children who, as part of welfare reform, were moved from the AFDC roles in Michigan into a new "workfare" program. The development and utilization of new methodological and biostatistical tools, career development, and dissemination activities coupled with the above research program will help to further establish the MICSIMB as a major international center for the study of mind/body interactions and physical health and mental health, cardiovascular disease, aging, and child development. This will be accomplished by a team of 21 experienced researchers from nine disciplines who will come together in a symbiotic way on five research projects and efforts to expand the methodological and biostatistical tools available for such analyses.