Michigan Interdisciplinary Center on Social Inequality, Mind & Body

我们建议继续并扩大一系列成功的跨学科合作，目前由P-50密歇根社会不平等、心理和身体跨学科中心资助。随着从P50中心到R24中心的转变，MICSIMB将强调资助研究项目的支持核心，加强这些项目的研究，以及探索性/先导性研究。R-24 MICSIMB将支持一个创新的跨学科研究计划的扩展，该计划寻求了解与健康有关的心理社会因素(信仰、态度、情感状态、价值观、压力和社会关系)的关系，它们更广泛的社会、社区和心理前因，以及 心理社会因素及其前驱因素促进身体和精神障碍发展的病理生理学途径。这项研究将涵盖从婴儿期和儿童期到成年和老年的整个生命过程中的人类发展，考虑广泛的身心健康结果，重点是老龄化、人类发展和心血管疾病，并将重点放在健康差异、生命过程方法、空间分析/邻里效应、基因-环境相互作用和方法创新上。研究改进将利用密歇根大学提供的大量正在进行的活动和存档数据，这些数据代表了超过20万人的不同、具有代表性的研究人群的信息。这些活动涵盖了一系列主题，从分析邻里和社区因素以及心理社会因素在健康中的作用，到基因和社会经济之间的相互作用。 和心理社会环境对高血压和痴呆的影响。这种方法将建立在大量研究之前的努力的基础上，并代表着一种非常具有成本效益的方法，以解决我们一直如此成功地进行的扩展的身心研究计划中的关键问题。参与的将是一个由22名核心调查人员组成的非常有成就的跨学科小组，他们跨越大学的16个单位，发表了超过1,000篇被引用超过22,000次的科学论文，其中至少85%的论文与拟议的中心扩建有关。

We propose to continue and expand a successful series of interdisciplinary collaborations currently funded as the P-50 Michigan Interdisciplinary Center on Social Inequalities, Mind, and Body. Consistent with the change from a P50 to an R24 Center, the MICSIMB will emphasize support cores for funded research projects, research enhancements to these projects, and exploratory/pilot studies. The R-24 MICSIMB will support the expansion of an innovative interdisciplinary research program seeking to understand the relationships of psychosocial factors related to health (beliefs, attitudes, affective states, values, stress and social relationships), their broader social, community, and psychological antecedents, and the pathophysiologic pathways through which psychosocial factors and their antecedents contribute to the development of physical and mental disorders. The research will encompass human development over the full life course from infancy and childhood through adulthood and older age, consider a broad range of physical and mental health outcomes, with some emphasis on aging, human development, and cardiovascular disease, and have important foci on health disparities, life course approaches, spatial analysis/neighborhood effects, gene-environment interaction, and methodological innovation. The research enhancements will make use of a large set of ongoing activities and archived data available at the University of Michigan, representing information on diverse, representative study populations of over 200,000 people. The activities cover a range of topics from analysis of the role of neighborhood and community factors and psychosocial factors in health, to interactions between genes and the socioeconomic and psychosocial environment in hypertension and dementia. Such an approach will build on the previous efforts of a large number of studies and represents a very cost-effective approach to addressing critical issues in the expanded program of mind-body research that we have been carrying on so successfully. Participating will be a very accomplished interdisciplinary group of 22 core investigators, spanning 16 units across the University who have published over 1,000 scientific papers that have been cited more than 22,000 times with at least 85% of these papers relevant to the proposed Center expansion.