Core--Methodology /Biostatistics

描述（摘自研究者摘要）：密歇根州社会不平等，心灵和身体跨学科中心（MICSIMB）将促进跨学科研究计划，寻求了解心理社会状态的相互作用（信念、态度、情感状态、价值观和社会关系），它们的决定因素、压力和压力的病理生理标志物，在身心障碍的发展中，在儿童发育和衰老方面。调查人员重点关注健康方面的社会经济和种族不平等，以及以社区为基础的儿童和成人，男性和女性以及少数民族样本中的生命历程和社区决定因素。这些项目代表了新颖的、具有成本效益的和相互关联的调查：（1）儿童的身体、情感和认知状态在多大程度上反映了父母社会经济地位、收入轨迹、经济压力和社区特征的影响;（2）糖皮质激素和肾上腺素能机制在心理社会状态、SES和CVD过度风险之间的关联中的作用;（3）在一个多层次的代表性社区样本中，利用社区因素的最新评估技术，研究广泛的心理属性、其前因和健康后遗症以及相关的压力生物标志物之间的相互关系;（4）社会经济、生物、和心理社会因素在不同阶段的生活过程中的广泛指标的心理社会福祉，心血管危险因素，亚临床和诊断的心血管疾病在成年期，使用的数据反映了超过50年的评估;（5）长期的经济压力，在原地，对健康和功能的影响，在一个随机选择的队列贫困妇女与年幼的孩子，作为福利改革的一部分，从AFDC的角色在密歇根州转移到一个新的“工作福利”计划。开发和利用新的方法和生物统计工具，职业发展和传播活动，加上上述研究计划，将有助于进一步建立MICSIMB作为一个主要的国际中心，研究心灵/身体相互作用和身体健康和心理健康，心血管疾病，老龄化和儿童发展。这将由来自9个学科的21名经验丰富的研究人员组成的团队完成，他们将以共生的方式共同开展5个研究项目，并努力扩大可用于此类分析的方法和生物统计工具。

DESCRIPTION (adapted from investigator's abstract): The Michigan Interdisciplinary Center on Social Inequalities, Mind, and Body (MICSIMB), will foster an interdisciplinary research program seeking to understand the interactions of psychosocial states (beliefs, attitudes, affective states, values, and social relationships), their determinants, stress, and pathophysiologic marker of stress, in the development of physical and mental disorders, in child development, and in aging. The investigators include a focus on socioeconomic and racial inequalities in health, and on lifecourse and community determinants in community-based samples of children and adults, men and women, and minorities. The projects represent novel, cost-effective, and interrelated investigations of: (1) the extent to which children's physical, emotional, and cognitive status reflect the influence of parental socioeconomic status, income trajectories economic stress, and community characteristics; (2) the role of glucocorticoid and serotonergic mechanisms in the associations between psychosocial states, SES, and excess risk for CVD; (3) the interrelations between a broad array of psychological attributes, their antecedents and health sequelae, and related biological markers of stress, within a multilevel representative community sample, utilizing state of the art assessment of community factors; (4) contributions of socioeconomic, biological, and psychosocial factors at different stages of the life course to a broad range of indicators of psychosocial well-being, cardiovascular risk factors, subclinical and diagnosed CVD in adulthood, using data reflecting over 50 years of assessments; and, (5) the impact of chronic economic stress, in situ, on health and function in a randomly selected cohort of poor women with young children who, as part of welfare reform, were moved from the AFDC roles in Michigan into a new "workfare" program. The development and utilization of new methodological and biostatistical tools, career development, and dissemination activities coupled with the above research program will help to further establish the MICSIMB as a major international center for the study of mind/body interactions and physical health and mental health, cardiovascular disease, aging, and child development. This will be accomplished by a team of 21 experienced researchers from nine disciplines who will come together in a symbiotic way on five research projects and efforts to expand the methodological and biostatistical tools available for such analyses.