MENTAL RETARDATION AND DEVELOPMENTAL PSYCHOPATHOLOGY

智力低下和发育心理病理学

• 批准号: 6520658
• 负责人: DONALD J COHEN
• 金额: $ 128.52万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6520658
• 关键词: behavioral /social science research tag; child mental disorders; child psychology; human subject; mental retardation

This application requests five years of continued support for a Multi- disciplinary program of research on Mental Retardation and Developmental Psychopathology. The Program emphasizes the interaction of neuromaturational genetic, and environmental factors in the emergence, course of specific syndromes as well as the development of individuals with mental retardation and developmental disorders. The program is unified by shared theoretical perspectives, methods, and research strategies. Processes are studied at various levels, including genetic, molecular, brain functioning, neuropsychology, clinical symptomatology, and adaptation and competence of retarded individuals as whole people. A particular concern is the interaction of neurobiological and neuropsychological factors in the understanding and aspects of competence as well as disability. The research Project areas focus on major domains of theoretical and clinical importance in relation to understanding of mental retardation and developmental disorders. Regulation of arousal and attention to conditions of environmental and biological risk, Interaction of genetic and biological factors in the pathogenesis of Tourette's syndrome and associated disorders, Autism and Asperger Syndrome-neurocognitive studies of social development and Neurobiological and developmental processes in genetic forms of mental retardation: Williams, Prader-Willi, and autism. The Program Project includes a range of specific syndromes and disorders, including autism, Asperger, Tourette's Syndrome, Obsessive-compulsive disorder, Attention Deficit Hyperactivity Disorder, Prader-Willi, and Williams syndromes, as well as children with developmental difficulties related to exposure to drugs and psychosocial adversity. These conditions are studied as important in their own right as clinical conditions and also as models for studying gene-environment interaction, developmental mechanisms, and developmental process over the course of life. Neuropsychological, behavioral, genetic, brain-function, developmental and other findings an be compared across the various diagnostic groups, to clarify basic mechanisms (such as the development of social competence) and clinical correlates (such as arousal/attentional or obsessive-compulsive symptomatology). The Program is also supported by Core Research Resources: Assessment and Biostatistics and Methodology. These core resources provide state-of-the-art collaboration and consultation for all of the Project Areas.

本申请要求对智力迟钝和发展性精神病理学的多学科研究项目提供五年的持续支持。该计划强调神经成熟的遗传和环境因素在特定综合征的出现，过程中的相互作用，以及精神发育迟滞和发育障碍个体的发展。 该方案是统一的共享理论观点，方法和研究策略。过程在各个层面上进行研究，包括遗传学，分子学，大脑功能，神经心理学，临床神经病学，以及弱智个体作为整个人的适应和能力。一个特别关注的是在理解能力和残疾方面的神经生物学和神经心理学因素的相互作用。研究项目领域集中在理论和临床重要性的主要领域，与理解精神发育迟滞和发育障碍有关。调节唤醒和注意环境和生物风险的条件，遗传和生物因素在抽动秽语综合征和相关疾病的发病机制中的相互作用，自闭症和艾伯格综合征-社会发展的神经认知研究和遗传形式的精神发育迟滞的神经生物学和发展过程：威廉姆斯，普拉德-威利和自闭症。该方案项目包括一系列具体的综合症和障碍，包括自闭症、自闭症、图雷特综合症、强迫症、注意缺陷多动障碍、普拉德-威利综合症和威廉姆斯综合症，以及与接触毒品和心理社会逆境有关的发育困难儿童。这些条件的研究本身就像临床条件一样重要，也可以作为研究基因-环境相互作用，发育机制和生命过程中发育过程的模型。神经心理学，行为，遗传，脑功能，发育和其他发现可以在不同的诊断组进行比较，以澄清基本机制（如社会能力的发展）和临床相关性（如唤醒/注意力或强迫症）。该计划还得到了核心研究资源的支持：评估和生物统计学和方法。这些核心资源为所有项目领域提供最先进的协作和咨询。