MENTAL RETARDATION AND DEVELOPMENTAL PSYCHOPATHOLOGY

该申请要求五年的持续支持，多- 心理学研究的学科、生物学和心理学计划 发育迟缓和发展性精神病理学。该方案强调， 神经成熟，遗传和环境因素的相互作用， 智力迟钝者的出现和自然过程 和发育障碍。该程序由一个共享的 理论视角、研究方法和研究策略。研究 涉及导致适应的进程和主管领域，以及 关于具体残疾和双重诊断（精神发育迟滞+ 精神病理学）在明确定义的综合征中。治疗研究是 提出了与基本的、潜在的机制有关的建议。 四个研究项目领域侧重于理论和 临床重要性的理解和改善 精神发育迟滞和发育障碍：1）发展 在子宫内接触毒品并在高风险环境中长大的儿童 环境：2）Tourette综合征和相关疾病作为模型 了解发育过程中基因与环境的相互作用 3）神经心理学和神经生物学的分化， 孤独症和自闭症综合征; 4）家族和遗传影响 对患有特定综合症的个体的发展轨迹 精神发育迟滞 该计划由三个核心研究资源支持： 管理;评估;和生物统计学和方法。这些 核心提供最先进的协作和咨询。

This application requests five years of continued support for a multi- disciplinary, biological, and psychological program of research of Mental Retardation and Developmental Psychopathology. The Program emphasizes the interaction of neuro-maturational, genetic, and environmental factors in the emergence and natural course of individuals with mental retardation and developmental disorders. The program is unified by a shared theoretical perspective, methods, and research strategies. Studies concern processes leading to adaptation and areas of competence, as well as to specific disabilities and dual diagnosis (mental retardation + psychopathology) in well-defined syndromes. Treatment studies are proposed that relate to basic, underlying mechanisms. The four Research Project Areas focus on major domains of theoretical and clinical importance in relation to the understanding and amelioration of mental retardation and developmental disorders: 1) the development of children exposed to drugs in utero and growing up in high-risk environments: 2) Tourette's syndrome and associated disorders as models for understanding gene-environment interaction in developmental disorders; 3) neuropsychological and neurobiological differentiation of autism and Asperger's syndrome; and 4) familial and genetic influences on the developmental trajectories of individuals with specific syndromes of mental retardation. The program is supported by three Core Research Resources: Administration; Assessment; and Biostatistics and Methodology. These Cores provide state-of-the art collaboration and consultation.