MENTAL RETARDATION AND DEVELOPMENTAL PSYCHOPATHOLOGY

智力低下和发育心理病理学

• 批准号: 2194808
• 负责人: DONALD J COHEN
• 金额: $ 73.51万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2194808
• 关键词: child mental disorders; child psychology; human subject; mental retardation

This application requests five years of continued support for a multi- disciplinary, biological, and psychological program of research of Mental Retardation and Developmental Psychopathology. The Program emphasizes the interaction of neuro-maturational, genetic, and environmental factors in the emergence and natural course of individuals with mental retardation and developmental disorders. The program is unified by a shared theoretical perspective, methods, and research strategies. Studies concern processes leading to adaptation and areas of competence, as well as to specific disabilities and dual diagnosis (mental retardation + psychopathology) in well-defined syndromes. Treatment studies are proposed that relate to basic, underlying mechanisms. The four Research Project Areas focus on major domains of theoretical and clinical importance in relation to the understanding and amelioration of mental retardation and developmental disorders: 1) the development of children exposed to drugs in utero and growing up in high-risk environments: 2) Tourette's syndrome and associated disorders as models for understanding gene-environment interaction in developmental disorders; 3) neuropsychological and neurobiological differentiation of autism and Asperger's syndrome; and 4) familial and genetic influences on the developmental trajectories of individuals with specific syndromes of mental retardation. The program is supported by three Core Research Resources: Administration; Assessment; and Biostatistics and Methodology. These Cores provide state-of-the art collaboration and consultation.

该申请要求五年的持续支持 心理研究的学科、生物学和心理学计划 发育迟缓和发育精神病理学。该计划强调 神经成熟、遗传和环境因素的相互作用 智力低下个体的出现和自然过程 和发育障碍。该程序由共享的统一 理论视角、方法和研究策略。研究 还关注导致适应的过程和能力领域 关于特定残疾和双重诊断（精神发育迟滞+ 精神病理学）在明确的综合征中。治疗研究是 提出与基本的、根本的机制有关的建议。 四个研究项目领域侧重于理论和研究的主要领域 与理解和改善相关的临床重要性 智力低下和发育障碍：1）发育 儿童在子宫内接触毒品并在高风险环境中成长 环境：2）抽动秽语综合症和相关疾病作为模型 理解发育过程中基因与环境的相互作用 疾病； 3）神经心理学和神经生物学的分化 自闭症和阿斯伯格综合症； 4) 家族和遗传影响 关于患有特定综合症的个体的发展轨迹 的精神发育迟滞。 该计划由三个核心研究资源支持： 行政;评估;以及生物统计学和方法论。这些 核心提供最先进的协作和咨询。