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Convection Enhanced Delivery Of Macromolecular Agents

Convection Enhanced Delivery Of Macromolecular Agents
对流增强大分子制剂的输送
批准号：
6548666
负责人：
Peter M Bungay
金额：
$0.0万
依托单位：
OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6548666
关键词：
antineoplastics biomedical equipment development injection /infusion macromolecule neoplasm /cancer chemotherapy

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相关文献

中文摘要
翻译
寻求一种将大分子药物输送到实体肿瘤和其他病变组织的方法的改进。这种方法被称为对流增强递送，是一种通过输注向靶组织间质递送的方法。输注剂通过输液溶液的整体流动穿过间质，以实现比扩散发生的更快的空间扩散。通常，由于沿输液插管的轨迹发生不希望的泄漏，这样的输液被限制在每分钟亚微升的流速。这一限制可以通过对套管进行修改以提供更大的表面积以使输液进入组织来克服。目前正在研究各种插管设计。
英文摘要
Improvement is sought for an approach to the delivery of macromolecular agents to solid tumors and other diseased tissue. The approach, which has been termed "convection-enhanced delivery", is one of delivery to target tissue interstitium by infusion. Infused agents are carried through the interstitium by the bulk flow of the infusate solution to achieve more rapid spatial spread than would occur by diffusion. Typically, such infusions have been limited to submicroliter per minute flow rates by the occurrence of undesired leakage along the track of the infusion cannula. This limitation may be overcome by cannula modification to provide a greater surface area for entry of the infusate into the tissue. Various cannula designs are being investigated.
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