Cannula Improvements for Convection-Enhanced Delivery of

用于对流增强输送的插管改进

• 批准号: 6837005
• 负责人: Peter M Bungay
• 金额: --
• 依托单位: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6837005
• 关键词: antineoplastics; biomedical equipment development; catheterization; drug delivery systems; injection /infusion; macromolecule; neoplasm /cancer chemotherapy

Improvement is sought for an approach to the delivery of macromolecular agents to solid tumors and other diseased tissue. The approach, which has been termed "convection-enhanced delivery," is one of delivery to target tissue interstitium by infusion. Infused agents are carried through the interstitium by the bulk flow of the infusate solution to achieve more rapid spatial spread than would occur by diffusion. Typically, such infusions have been limited to submicroliter per minute flow rates by the occurrence of undesired leakage along the track of the infusion cannula. This limitation may be overcome by cannula modification to provide a greater surface area for entry of the infusate into the tissue. Various cannula designs are being investigated.

寻求改进将大分子试剂递送至实体瘤和其它患病组织的方法。该方法被称为“对流增强递送”，是通过输注递送至靶组织的方法之一。输注的药剂通过输注溶液的整体流动通过微囊，以实现比通过扩散发生的更快的空间扩散。通常，由于沿着输注套管的轨道沿着发生不希望的泄漏，这种输注被限制在亚微升/分钟的流速。这种限制可以通过套管修改来克服，以提供更大的表面积用于输注物进入组织。正在研究各种套管设计。