Pharmacokinetic Models Of Tumor Targeting

建立了数学模型来描述单克隆抗体全身给药后血管前球形肿瘤结节和周围正常组织中抗体浓度的时间过程。这些模型预期用于设计和评价使用抗体检测或治疗癌症微转移的方案。该模型纳入了影响正常和肿瘤组织中抗体水平的以下因素：血浆动力学、跨毛细血管转运、淋巴清除以及由结合反应和扩散引起的抗体浓度的空间变化。说明性的数值模拟采用有限元方法求解微分方程。进行了敏感性分析，以确定其幅度将是重要的影响的协议的效用的参数。

Mathematical models were developed to describe the time course of antibody concentrations in a prevascular spherical tumor nodule and the surrounding normal tissue following bolus systemic administration of monoclonal antibody. The models are intended for use in designing and evaluating protocols for the use of antibodies in detection or treatment of cancer micrometastases. The models incorporate the following factors that affect antibody levels in the normal and tumor tissues: plasma kinetics, transcapillary transport, lymphatic clearance, and spatial variation in antibody concentration arising from binding reactions and diffusion. Illustrative numerical simulations were performed employing finite element methods to solve the differential equations. Sensitivity analyses were conducted to identify the parameters whose magnitude would be important in influencing the utility of the protocols.