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Modifications To Convection-Enhanced Delivery Of Macromo

Modifications To Convection-Enhanced Delivery Of Macromo
Macromo 对流增强输送的改进
批准号：
6684995
负责人：
Peter M Bungay
金额：
$0.0万
依托单位：
OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6684995
关键词：
antineoplastics biomedical equipment development injection /infusion macromolecule neoplasm /cancer chemotherapy

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中文摘要
翻译
寻求一种将大分子药物输送到实体肿瘤和其他病变组织的改进方法。这种方法被称为“对流增强输送”，是一种通过输注输送到靶组织间质的方法。注入的药物由注入溶液的大量流动携带通过间质，以实现比扩散更快的空间扩散。通常情况下，这种输注被限制在每分钟亚微升的流速，因为沿着输注套管的轨迹发生了不希望的泄漏。这一限制可以通过修改套管来克服，以提供更大的表面积使输液进入组织。各种套管设计正在研究中。
英文摘要
Improvement is sought for an approach to the delivery of macromolecular agents to solid tumors and other diseased tissue. The approach, which has been termed "convection-enhanced delivery," is one of delivery to target tissue interstitium by infusion. Infused agents are carried through the interstitium by the bulk flow of the infusate solution to achieve more rapid spatial spread than would occur by diffusion. Typically, such infusions have been limited to submicroliter per minute flow rates by the occurrence of undesired leakage along the track of the infusion cannula. This limitation may be overcome by cannula modification to provide a greater surface area for entry of the infusate into the tissue. Various cannula designs are being investigated.
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