Adaptation To Pain And Stress In Fibromyalgia

纤维肌痛对疼痛和压力的适应

• 批准号: 6511973
• 负责人: ALEX J ZAUTRA
• 金额: $ 50.43万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-08 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6511973
• 关键词: behavioral /social science research tag; chronic pain; comorbidity; coping; electromyography; female; fibromyalgia; field study; functional ability; human middle age (35-64); human subject; interpersonal relations; interview; longitudinal human study; mental health; osteoarthritis; pain threshold; pathologic process; patient oriented research; physiologic stressor; psychological adaptation; questionnaires; social adjustment; social support network; statistics /biometry; women's health

APPLICANT?S DESCRIPTION: This grant focuses on individual differences in the stress response as significant factors determining who develops a chronic pain syndrome characterized by widespread pain, and who is unable to recover from it. Maladaptive responses to pain and withdrawal from positive social interactions are studied as key factors that underlie the affective distress and persistence of fibromyalgia symptoms. To test this model three well established methods of inquiry are used: 1. Field assessments of responses to stress, developed in prior research on arthritis patients, and 2. Laboratory tests of stress reactivity under controlled experimental conditions. 3. Longitudinal follow-up of patient status 2 years after pre-tests. Two groups of Osteoarthritis participants are studied: (1) 150 OA participants who meet criteria for Fibromyalgia (FM), and (2) 200 participants with osteoarthritis (OA) who report levels of pain comparable to the FM group, but who do not display the classic tender point symptoms found among those with FM. Longitudinal assessments on all subjects as well as thorough initial testing will permit three types of comparisons. 1.The examination of case-control differences between groups of FM respondents and those with OA only. 2.The examination of variables predictive of recovery among those with FM. 3. The examination of those factors predictive of the onset of widespread pain among the OA sample that displayed only regional pain at the initial assessment.

申请者？S描述：这笔助学金侧重于 压力反应是决定谁会出现慢性疼痛的重要因素 以广泛性疼痛为特征的综合症，无法从 它。对疼痛和积极社交中的退缩的适应不良反应 交互作用作为情感困扰的关键因素被研究。 和持续性的纤维肌痛症状。为了很好地测试这款模型 采用既定的调查方法：1.对以下问题的答复进行实地评估 压力，在先前对关节炎患者的研究中发展起来的，以及2.实验室 在受控实验条件下的应力反应性测试。3. 预试验后2年对患者状态进行纵向随访。两组 骨关节炎参与者的研究：(1)150名骨关节炎参与者 纤维肌痛(FM)的标准，以及(2)200名患有骨关节炎的参与者 (OA)报告的疼痛程度与FM组相当，但不是 显示在FM患者中发现的经典痛点症状。 对所有科目进行纵向评估以及彻底的初步测试 将允许三种类型的比较。1.病例对照检查 FM受访者和仅患有OA的人群之间的差异。2.The FM患者中预测康复的变量的检查。3. 检查那些预测广泛性疼痛发生的因素 最初评估时仅显示局部疼痛的OA样本。