Adaptation To Pain And Stress In Fibromyalgia

纤维肌痛对疼痛和压力的适应

• 批准号: 6511973
• 负责人: ALEX J ZAUTRA
• 金额: $ 50.43万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-08 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6511973
• 关键词: behavioral /social science research tag; chronic pain; comorbidity; coping; electromyography; female; fibromyalgia; field study; functional ability; human middle age (35-64); human subject; interpersonal relations; interview; longitudinal human study; mental health; osteoarthritis; pain threshold; pathologic process; patient oriented research; physiologic stressor; psychological adaptation; questionnaires; social adjustment; social support network; statistics /biometry; women's health

APPLICANT?S DESCRIPTION: This grant focuses on individual differences in the stress response as significant factors determining who develops a chronic pain syndrome characterized by widespread pain, and who is unable to recover from it. Maladaptive responses to pain and withdrawal from positive social interactions are studied as key factors that underlie the affective distress and persistence of fibromyalgia symptoms. To test this model three well established methods of inquiry are used: 1. Field assessments of responses to stress, developed in prior research on arthritis patients, and 2. Laboratory tests of stress reactivity under controlled experimental conditions. 3. Longitudinal follow-up of patient status 2 years after pre-tests. Two groups of Osteoarthritis participants are studied: (1) 150 OA participants who meet criteria for Fibromyalgia (FM), and (2) 200 participants with osteoarthritis (OA) who report levels of pain comparable to the FM group, but who do not display the classic tender point symptoms found among those with FM. Longitudinal assessments on all subjects as well as thorough initial testing will permit three types of comparisons. 1.The examination of case-control differences between groups of FM respondents and those with OA only. 2.The examination of variables predictive of recovery among those with FM. 3. The examination of those factors predictive of the onset of widespread pain among the OA sample that displayed only regional pain at the initial assessment.

申请人的描述：该赠款重点介绍 压力反应是决定谁发展慢性疼痛的重要因素 综合症以广泛的疼痛为特征，无法从中恢复过 它。对疼痛和从积极社会中退出的不良适应性反应 研究相互作用是影响情感困扰的关键因素 和纤维肌痛症状的持久性。测试该模型三井 使用了既定的查询方法：1。对响应的现场评估 在关节炎患者的先前研究中发展的压力，2。 在受控的实验条件下应力反应性的测试。 3。 预测试后2年对患者状况的纵向随访。两组 研究了骨关节炎参与者：（1）150位OA参与者 纤维肌痛（FM）的标准和（2）200名参与者骨关节炎 （OA）报告的疼痛程度可与FM组相当，但没有 在患有FM的人中显示经典的招标点症状。 对所有受试者以及彻底初始测试的纵向评估 将允许三种类型的比较。 1.病例对照的检查 FM受访者组与仅具有OA的人之间的差异。 2. 检查FM患者之间恢复的变量的检查。 3 检查这些因素，可预测到广泛疼痛的发作 在初步评估时仅显示区域疼痛的OA样品。