Adaptation To Pain And Stress In Fibromyalgia

纤维肌痛对疼痛和压力的适应

• 批准号: 6906529
• 负责人: ALEX J ZAUTRA
• 金额: $ 34.4万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-08 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6906529
• 关键词: behavioral /social science research tag; chronic pain; comorbidity; coping; electromyography; female; fibromyalgia; field study; functional ability; human middle age (35-64); human subject; interpersonal relations; interview; longitudinal human study; mental health; osteoarthritis; pain threshold; pathologic process; patient oriented research; physiologic stressor; psychological adaptation; questionnaires; social adjustment; social support network; statistics /biometry; women' s health

APPLICANT?S DESCRIPTION: This grant focuses on individual differences in the stress response as significant factors determining who develops a chronic pain syndrome characterized by widespread pain, and who is unable to recover from it. Maladaptive responses to pain and withdrawal from positive social interactions are studied as key factors that underlie the affective distress and persistence of fibromyalgia symptoms. To test this model three well established methods of inquiry are used: 1. Field assessments of responses to stress, developed in prior research on arthritis patients, and 2. Laboratory tests of stress reactivity under controlled experimental conditions. 3. Longitudinal follow-up of patient status 2 years after pre-tests. Two groups of Osteoarthritis participants are studied: (1) 150 OA participants who meet criteria for Fibromyalgia (FM), and (2) 200 participants with osteoarthritis (OA) who report levels of pain comparable to the FM group, but who do not display the classic tender point symptoms found among those with FM. Longitudinal assessments on all subjects as well as thorough initial testing will permit three types of comparisons. 1.The examination of case-control differences between groups of FM respondents and those with OA only. 2.The examination of variables predictive of recovery among those with FM. 3. The examination of those factors predictive of the onset of widespread pain among the OA sample that displayed only regional pain at the initial assessment.

申请人？S描述：该补助金侧重于个人差异， 压力反应是决定谁发展为慢性疼痛的重要因素 综合征的特点是广泛的疼痛，谁是无法恢复， 了对疼痛的适应不良反应和从积极的社交活动中退缩 交互作用被认为是情感困扰的关键因素 和纤维肌痛症状的持续性。为了测试这个模型， 采用既定的调查方法：1.对应对措施的实地评估 压力，在先前对关节炎患者的研究中开发，和2.实验室 在受控实验条件下的应力反应性测试。3. 预试验后2年对患者状态进行纵向随访。两组 研究骨关节炎参与者：（1）150名OA参与者， 纤维肌痛（FM）标准，和（2）200名骨关节炎受试者 (OA)报告疼痛程度与FM组相当，但 显示出FM患者的典型压痛点症状。 对所有受试者进行纵向评估以及全面的初始测试 将允许三种类型的比较。1.病例对照检验 FM应答者和仅OA应答者之间的差异。2.The 检查预测FM患者康复的变量。3.的 检查那些预测广泛疼痛发作的因素， 在初始评估时仅显示局部疼痛的OA样本。

项目成果

COMT moderates the relation of daily maladaptive coping and pain in fibromyalgia.

• DOI: 10.1016/j.pain.2010.10.024
• 发表时间: 2011-02
• 期刊: Pain
• 影响因子: 7.4
• 作者: Finan PH;Zautra AJ;Davis MC;Lemery-Chalfant K;Covault J;Tennen H
• 通讯作者: Tennen H

Genetic influences on the dynamics of pain and affect in fibromyalgia.

• DOI: 10.1037/a0018647
• 发表时间: 2010-03
• 期刊: HEALTH PSYCHOLOGY
• 影响因子: 4.2
• 作者: Finan, Patrick H.;Zautra, Alex J.;Davis, Mary C.;Chalfant, Kathryn Lemery;Covault, Jonathan;Tennen, Howard
• 通讯作者: Tennen, Howard

Relationship status and quality moderate daily pain-related changes in physical disability, affect, and cognitions in women with chronic pain.

• DOI: 10.1016/j.pain.2012.10.004
• 发表时间: 2013-01
• 期刊: Pain
• 影响因子: 7.4
• 作者: Taylor SS;Davis MC;Zautra AJ
• 通讯作者: Zautra AJ

Fibromyalgia: evidence for deficits in positive affect regulation.

纤维肌痛：积极情感调节缺陷的证据。

• DOI: 10.1097/01.psy.0000146328.52009.23
• 发表时间: 2005
• 期刊: Psychosomatic medicine
• 影响因子: 3.3
• 作者: Zautra,AlexJ;Fasman,Robert;Reich,JohnW;Harakas,Peter;Johnson,LisaM;Olmsted,MaureenE;Davis,MaryC
• 通讯作者: Davis,MaryC

A multilevel structural equation modeling analysis of vulnerabilities and resilience resources influencing affective adaptation to chronic pain.

• DOI: 10.1016/j.pain.2013.10.007
• 发表时间: 2014-02
• 期刊: Pain
• 影响因子: 7.4
• 作者: Sturgeon JA;Zautra AJ;Arewasikporn A
• 通讯作者: Arewasikporn A