Proposal for a Chicago-CRIC Clinical Center

芝加哥-CRIC 临床中心提案

• 批准号: 6524674
• 负责人: JAMES P. LASH
• 金额: $ 47.56万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-28 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6524674
• 关键词: blood chemistry; cardiovascular disorder; cardiovascular imaging /visualization; chronic renal failure; clinical research; cooperative study; disease /disorder proneness /risk; epidemiology; glomerular filtration rate; human morbidity; human mortality; human subject; longitudinal human study; noninvasive diagnosis; urinalysis

DESCRIPTION(provided by applicant): Individuals with chronic renal insufficiency (CRI) represent a large and growing segment of our population, with much of the recent growth fueled by the increased incidence of diabetes. The adverse impact of cardiovascular disease (CVD) in the end stage renal disease (ESRD) population has its beginnings earlier, during the course of CRI, but associated risk factors have not been completely characterized. The overlap between several CVD and renal disease risk factors suggests interactions between CRI and CVD that are not completely understood. The primary goals of the Prospective Cohort Study of Chronic Renal Insufficiency (CRIC) are to determine the risk factors for accelerated decline in renal function and to determine the incidence of, and identify risk factors for, cardiovascular disease in the CRI population. The proposed Chicago-CRIC Consortium is a group of closely tied institutions with a history of previous collaborations, serving a geographically compact and densely populated area, serving an adult patient population of several million among which an estimated 96,000 have CRI with GFRs in the range of 30-70 ml/min/1.73m2. Using our previously effective strategies in recruiting for the NIH-sponsored African American Study of Kidney Disease and Hypertension (AASK) and HEMO trials, we will recruit and retain 500 men and women with chronic renal insufficiency (CRI) from patients served by Chicago-CRIC institutions. The Chicago-CRIC Clinical Center will provide yearly Comprehensive Visits for six to seven years, which will include 125-iothalamate GFRs, blood pressure measurements, anthropometrics, urine and blood testing, and cardiovascular imaging (electron beam tomograpy [EBT], echocardiography, and carotid ultrasound). In addition, we will provide regular morbidity and mortality follow-up, which will include the tracking and classification of renal and cardiovascular endpoints. The strengths of the Chicago-CRIC Clinical Center are the established history of collaboration between the member institutions, our experience as investigators in two previous large NIH multicenter clinical studies involving renal patients (AASK and HEMO), the utilization of an existing, N1H-funded General Clinical Research Center (GCRC) for all study visits, and our ability to access databases containing a very large CRI population.

描述（由申请人提供）： 慢性肾功能不全（CRI）患者是一个大的， 我们人口中越来越多的部分，最近的增长大部分是由 糖尿病发病率增加。心血管疾病的不良影响 (CVD)在终末期肾病（ESRD）人群中， 早期，在CRI的过程中，但相关的风险因素尚未被 完全特征化。几种CVD和肾脏疾病之间的重叠 风险因素表明CRI和CVD之间的相互作用并不完全 明白慢性肾功能衰竭前瞻性队列研究的主要目的 不充分（CRIC）是为了确定加速下降的风险因素 在肾功能和确定的发病率，并确定危险因素 对于CRI人群中的心血管疾病。拟议的芝加哥-审评委 财团是一组紧密联系的机构， 协作，服务于地理位置紧凑且人口稠密的地区， 为数百万成年患者提供服务， 96，000人的CRI，GFR在30-70 ml/min/1.73 m2范围内。使用我们 以前有效的策略，在招募美国国立卫生研究院赞助的非洲 美国肾脏疾病和高血压研究（AASK）和HEMO试验，我们 将招募并保留500名患有慢性肾功能不全的男性和女性 (CRI)来自芝加哥-CRIC机构服务的患者。芝加哥-审评委 临床中心将每年提供6至7次综合访视 年，其中将包括125-碘酞酸GFR，血压测量， 人体测量、尿液和血液检测以及心血管成像（电子 射束断层扫描[EBT]、超声心动图和颈动脉超声）。此外，本发明还提供了一种方法， 我们将定期提供发病率和死亡率随访，其中包括 肾脏和心血管终点的跟踪和分类。的 芝加哥-CRIC临床中心的优势是 成员机构之间的合作，我们作为调查人员的经验 在之前两项涉及肾病患者的大型NIH多中心临床研究中， (AASK和HEMO），利用现有的，N1 H资助的一般临床 研究中心（GCRC）的所有研究访视，以及我们访问 包含大量CRI人群的数据库。