VESTIBULAR AFFERENT ACTIVITY AFTER CANAL PLUGGING

说明： 堵塞相互对应的半规管可消除这种反应 与围绕其关联轴以0.2的频率旋转相关联 赫兹。在更高的频率下，存在空间的非正规化 角状前庭-眼反射(AVOR)的反应。的假说 这项研究认为，这种归一化的发生是因为封堵不会 消除堵塞的运河的反应。相反，它改变了运河 动力学，从而降低了运河的主要时间常数。在… 目前，没有直接证据表明堵塞的管道传入对 以更高的频率旋转。中枢性前庭活动也没有 在运河堵塞后进行了研究，以确定是否真的有 空间适应。目标工作将解决以下问题： 渠道堵塞是否改变了河流的时空特征？ 感觉神经元对轮换的反应？城市的空间特征将如何 中枢性前庭神经元受侧管堵塞和 通过横管神经的切面？前庭的前庭传入 在双侧外侧管前后记录食蟹猴 堵住了。预计侧管的调制幅度 插入后，传入信号在0.2赫兹时将接近于零，但会趋于 当磁头振荡频率增加到4.0赫兹时，使磁头非正规化。 垂直通道传入应保持正常频率 特点。空间动眼神经与前庭中央神经元 我们将比较双侧神经切开后的反应和 封堵后确定是否有明显的空间 神经切断后的适应。预计空间响应 会因中枢适应而改变，但在空间上的变化 作为频率函数的响应不会像运河那样显著 堵住了。这项工作应该会让我们更清楚地了解病变是如何， 如堵塞、神经切断等，影响头部的感觉加工 以及中央前庭系统如何适应这些类型的运动 损伤。

DESCRIPTION: Plugging of reciprocal semicircular canal pairs eliminates the response associated with rotation about their associated axis at a frequency of 0.2 Hz. At higher frequencies, there is a Anormalization of the spatial responses of the angular vestibulo-ocular reflex (aVOR). The hypothesis of this study is that this normalization occurs because plugging does not eliminate the respons of the plugged canal. Rather, it modifies the canal dynamics so that the dominant time constant of the canal is lowered. At present, there is no direct evidence that plugged canal afferents respond to rotation at higher frequencies. Neither has central vestibular activity been studied following canal plugging to determine if indeed there is spatial adaptation. The purpose work will address the following questions: Does canal plugging modify the spatial and temporal characteristics of the afferents in response to rotation? How will the spatial characteristics of central vestibular neurons be affected by plugging of the lateral canals and by section of the lateral canal nerves? Vestibular afferents of the cynomolgus monkeys will be recorded before and after bilateral lateral canal plugging. It is expected that the amplitude of modulation of lateral-canal afferents will be approximately zero at 0.2 Hz after plugging, but will tend to Anormalize as the head oscillation frequency is increased up to 4.0 Hz. Vertical canal afferents should maintain their normal frequency characteristics. Spatial oculomotor and central vestibular neuronal responses will be compared following bilateral sectioning of the nerves and after canal plugging to determine whether there is significant spatial adaptation following nerve cut. It is expected that the spatial responses will be altered due to central adaptation, but that changes in spatial responses as a function of frequency will not be as significant as for canal plugging. This work should lead to a clearer understanding of how lesions, such as plugging and nerve section, affect the sensory processing of head movements and how the central vestibular system adapts to these types of lesions.