Context-specific spatial adaptation of the VOR

VOR 的特定环境空间适应

• 批准号: 6468215
• 负责人: SERGEI YAKUSHIN
• 金额: $ 35.09万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6468215
• 关键词: Macaca fascicularis; balance; behavior test; behavioral /social science research tag; brain electrical activity; electrical measurement; environmental adaptation; gravity; microelectrodes; neural information processing; neural plasticity; neuropsychology; proprioception /kinesthesia; psychometrics; sensorimotor system; sensory receptors; space perception; vestibular apparatus; vestibular nerve; vestibular pathway; vestibuloocular reflex; visual perception

DESCRIPTION:(provided by applicant) The purpose of this research is to characterize how adaptation of the angular vestibulo-ocular (aVOR) reflex depends on head orientation with regard to gravity and to determine its neural basis. The horizontal, vertical and torsional component of the aVOR will be adaptively increased and decreased in cynomolgus monkey (Macaca fascicularis) with the head in different positions. Angular rotation that is in-phase or out-of-phase with the visual surround will be used to decrease or increase the gain of the aVOR, respectively. Data obtained before and after adaptation will be compared. Magnitude of adaptive changes in various head orientations will be studied after one of the aVOR components has been adapted in a particular head position. Functional dependence of context-specific gain changes will be determined for each aVOR component. We expect that the amount of gain change will be maximal with the head in the same position in which the aVOR was adapted, and that changes will decrease as the head is deviated from this position. Based on the results of this experiment, our previous aVOR model will be extended to account for context specific gain changes. The neuronal basis of the context specific adaptation will be studied. When these studies are completed, we will have characterized context specific adaptation for canal activation in any plane and will have provided insights into the neural basis for this adaptation. An understanding of the neural basis of the context specific adaptation with regard to gravity is of considerable scientific interest, because this type of knowledge could have important implications for understanding adjustments to visual-vestibular conflict in gravitational environments. We postulate that context specific adaptation is one of the basic properties of the aVOR that is critical for orientation in three-dimensional space in the presence of gravity. Therefore, understanding of this phenomenon will significantly advance our knowledge of how the canals and otolith interact to maintain gaze stability.

描述：（申请人提供） 本研究的目的是为了描述角的适应性 前庭-眼（aVOR）反射取决于头部方向， 重力并确定其神经基础。水平、垂直和 aVOR的扭转分量将自适应地增加和减少， 食蟹猴（Macaca fascicularis），头部处于不同位置。 与视觉环境同相或异相的角度旋转将 用于分别减小或增大aVOR的增益。数据 将比较适应之前和之后获得的结果。自适应幅度 在一次aVOR之后，将研究各种头部方向的变化 组件已在特定的头部位置进行了调整。功能 将为每个aVOR确定上下文特定增益变化的相关性 成分我们预期增益变化量将在 头在同一个位置，在其中的aVOR是适应，而变化将 当头部偏离该位置时减小。结果的基础上 在这个实验中，我们以前的aVOR模型将是 扩展以考虑上下文特定的增益变化。的神经基础 将研究特定于上下文的适应。当这些研究 完成后，我们将有特点的背景具体适应运河 在任何平面激活，并将提供深入了解神经基础 对于这种适应。理解语境的神经基础 关于重力的具体适应具有相当大的科学意义 因为这类知识可能对 理解在重力作用下视觉-前庭冲突的调节 环境.我们假设，特定语境适应是一个基本的 aVOR的性质对于三维中的取向至关重要， 在重力存在的情况下。因此，对这一现象的理解 将大大推进我们对运河和耳石如何相互作用的认识 以保持凝视稳定性。