Context-specific spatial adaptation of the VOR

描述：(申请人提供) 这项研究的目的是刻画角度如何适应 前庭-眼睛(Avor)反射取决于头部相对于 并确定其神经基础。水平、垂直和 Avor的扭转分量将自适应地增加和减少 食蟹猴(食蟹猴)，头部在不同的位置。 与视觉环境同相或异相的角度旋转将 分别用于降低或增加Avor的增益。数据 将改编前后得到的数据进行比较。自适应的幅度 在其中一个Avor之后，将研究不同头部方向的变化 部件已经在特定的头部位置进行了调整。功能性 将针对每个AVE确定特定于环境的增益更改的相关性 组件。我们预计增益的变化量将随着 头部的位置与阿凡达被改编的位置相同，而这一变化将 随着头部偏离此位置而减小。基于以下结果： 这个实验，我们之前的Avor模型将是 扩展以考虑到上下文特定的增益变化。神经细胞的基础 将研究特定于语境的适应。当这些研究是 完成后，我们将对运河的特定背景适应进行表征 任何平面上的激活，将提供对神经基础的洞察 为了这次改编。对语境神经基础的理解 关于重力的具体适应具有相当大的科学性 兴趣，因为这种类型的知识可能对 了解重力状态下视觉-前庭冲突的调节 环境。我们假设特定于语境的顺应是基本的顺应之一 对三维定向至关重要的Avor的属性 重力作用下的空间。因此，对这种现象的理解 将极大地促进我们对运河和耳石如何相互作用的了解 以保持凝视的稳定性。

DESCRIPTION:(provided by applicant) The purpose of this research is to characterize how adaptation of the angular vestibulo-ocular (aVOR) reflex depends on head orientation with regard to gravity and to determine its neural basis. The horizontal, vertical and torsional component of the aVOR will be adaptively increased and decreased in cynomolgus monkey (Macaca fascicularis) with the head in different positions. Angular rotation that is in-phase or out-of-phase with the visual surround will be used to decrease or increase the gain of the aVOR, respectively. Data obtained before and after adaptation will be compared. Magnitude of adaptive changes in various head orientations will be studied after one of the aVOR components has been adapted in a particular head position. Functional dependence of context-specific gain changes will be determined for each aVOR component. We expect that the amount of gain change will be maximal with the head in the same position in which the aVOR was adapted, and that changes will decrease as the head is deviated from this position. Based on the results of this experiment, our previous aVOR model will be extended to account for context specific gain changes. The neuronal basis of the context specific adaptation will be studied. When these studies are completed, we will have characterized context specific adaptation for canal activation in any plane and will have provided insights into the neural basis for this adaptation. An understanding of the neural basis of the context specific adaptation with regard to gravity is of considerable scientific interest, because this type of knowledge could have important implications for understanding adjustments to visual-vestibular conflict in gravitational environments. We postulate that context specific adaptation is one of the basic properties of the aVOR that is critical for orientation in three-dimensional space in the presence of gravity. Therefore, understanding of this phenomenon will significantly advance our knowledge of how the canals and otolith interact to maintain gaze stability.