EFFECTS OF AGING ON HUMAN SLEEP HOMEOSTASIS AND DYNAMICS

描述(摘自申请者的摘要)：增加白天的午睡时间， 随着年龄的增长，夜间睡眠的碎片化增加。然而，在那里 目前还没有关于午睡对后续生活的影响的系统研究 老年人夜间睡眠、睡眠满意度或情绪。这限制了我们的 能够为睡眠卫生开出合理的处方。我们已经在 年轻人的午睡时间对建筑有不同的影响 午睡后的夜间睡眠：在下午3点或更早的时候午睡会减少 计算机测量的三角洲仅在第一个NREM时期，而后来的NAPs 改变NAPs的临床疗效。我们已经进一步表明，德尔塔 白天午睡的发生是从午睡后的自我平衡中减去的 睡个好觉。目前的模型认为NREM三角洲是“休养生息的” 睡眠平衡的组成部分。提出的研究可能会导致 Delta最简单、最不费力、最便宜的临床测试 自闭症。拟议的研究还将确定这一比率 随着尾流的增加，增量累积遵循指数或 Logistic(增长)模型。这种区别可以指导关于 三角洲动态平衡的生物学，也允许更精确的定量 睡醒关系的典范。这些研究的科学成果 将通过以下方式进行增强：同时应用频谱(FFT)和 对数字化数据进行周期幅值分析，精确测量 年轻人和老年人的性别影响；德尔塔-西格玛和 老年人的Delta-beta振荡关系；以及对 假设快速眼动潜伏期，睡眠中研究最多的部分 在精神病患者中，这在很大程度上由三角洲压力决定。

DESCRIPTION (Adapted from applicant's abstract): Increased daytime naps, and increased fragmentation of nocturnal sleep, occur with aging. Yet there have been no systematic studies of the effects of naps on subsequent nocturnal sleep, sleep satisfaction or mood in the elderly. This limits our ability to make rational prescriptions for sleep hygiene. We have shown in young adults that the timing of naps differentially affects the architecture of post-nap night sleep: naps taken at 3 PM or earlier reduce computer-measured delta only in the first NREM period whereas later naps alter the clinical effects of naps. We have shown further that delta occurring in daytime naps is homeostatically "subtracted" from post-nap night sleep. Current models hold that NREM delta is the "recuperative" component of sleep homeostasis. The research proposed could lead to the simplest, least arduous and least expensive clinical test of delta homesostatasis. The proposed studies will also determine whether the rate of delta accumulation with increasing waking follows an exponential or logistic (growth) model. This distinction can guide hypotheses regarding the biology of delta homeostasis and also permit more precise quantitative models of sleep-waking relations. The scientific yield of these studies will be enhanced by: application of both spectral (FFT) and period-amplitude analysis to the digitized data, precise measurement of gender effects in young adults and elderly; measurement of delta-sigma and delta-beta oscillatory relations in the elderly; and an experimental test of the hypothesis that REM latency, the most heavily studied component of sleep in psychiatric patients, is substantially determined by delta pressure.