Diabetes Research for Pediatric Endocrinologists

儿科内分泌学家的糖尿病研究

• 批准号: 6584802
• 负责人: GEORGEANNA J KLINGENSMITH
• 金额: $ 28.63万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6584802
• 关键词: curriculum; diabetes education; diabetes mellitus; education evaluation /planning; endocrinology; health science research support; pediatrics

DESCRIPTION (provided by applicant): This application is part of a combined application for training of pediatric endocrinology fellows and junior pediatric endocrinology faculty. This training program is designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC) and The University of Colorado Health Sciences Center (UCHSC).This proposal's rationale is: 1) there is a critical shortage of pediatric endocrinologists in the country, particularly those trained and experienced in diabetes research 2) Diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economic point of view into the future. 3) Current rapid advances in diabetes investigation calls for an increased pool of physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out translation research in pediatric type 1 and type 2 diabetes to bring advances in diabetes research to the clinical arena. The Barbara Davis Center has extensive and a proven record in research training of young investigators. The BDC and UCHSC have a well established network of investigators working in the immunobiology, genetics, and molecular biology of type 1 diabetes, as well as the abnormal pathophysiology of type 2 diabetes. This network of experienced mentors is ideally suited to develop the next generation of young pediatric endocrinologists into independent diabetes investigators. Areas of research focus within The Barbara Davis Center include islet cell physiology, genetics, molecular biology, transplant immunology, and the autoimmunity, prediction and prevention of type 1 diabetes, and the epidemiology, prevention and treatment of type 1 and type 2 diabetes. This application is enhanced by the NIH supported Diabetes and Endocrinology Research Center, well established, NIH supported Pediatric and Adult Clinical Research Centers, and a Clinical Nutrition Research Unit, an NIH supported K30 Clinical Research Curriculum Award, as well as a strong Masters of Science in Public Health Program. This application has the support of the Departments of Pediatrics, Medicine, Preventive Medicine and The Children's Hospital of Denver. The ability to provide strong didactic coursework in statistics, epidemiology, research methods, ethics and regulation of human research, medical writing, biochemistry, pharmacokinetics and molecular biology, as well as human medical genetics and molecular genetics through the Program in Clinical Science, combined with a strong mentoring faculty at the BDC and UCHSC will allow us to provide the continuous training and development of young pediatric endocrinologists through their training and development into independent investigators, capable of being competitive for independent research funding and research activity. Other programs within UCHSC which will be supportive of this program include the Program in Human Genetics, The Immune Tolerance Network and the Autoimmune Prevention Center.

描述（由申请人提供）： 此应用程序是儿科内分泌学研究员和初级儿科内分泌学教师培训的联合应用程序的一部分。该培训计划旨在为芭芭拉戴维斯中心（BDC）和科罗拉多大学健康科学中心（UCHSC）提供糖尿病研究方面的多学科培训。该提案的基本原理是：1）该国儿科内分泌学家严重短缺，特别是那些受过糖尿病研究培训和经验丰富的人2）糖尿病是儿科人群中日益重要的医疗保健问题，从个人和健康经济的角度来看，未来会产生毁灭性的后果。3)目前糖尿病研究的快速进展要求增加在临床、生物化学、流行病学和行为研究方面接受过培训的医生科学家，以在儿科1型和2型糖尿病中进行转化研究，从而将糖尿病研究的进展带到临床竞技场。芭芭拉·戴维斯中心在年轻研究人员的研究培训方面有着广泛和可靠的记录。BDC和UCHSC拥有完善的研究人员网络，致力于1型糖尿病的免疫生物学，遗传学和分子生物学以及2型糖尿病的异常病理生理学。这个由经验丰富的导师组成的网络非常适合将下一代年轻的儿科内分泌学家培养成独立的糖尿病研究者。芭芭拉戴维斯中心的研究重点领域包括胰岛细胞生理学，遗传学，分子生物学，移植免疫学，自身免疫，预测和预防1型糖尿病，流行病学，预防和治疗1型和2型糖尿病。该应用程序得到了NIH支持的糖尿病和内分泌学研究中心的加强，该研究中心已建立，NIH支持的儿科和成人临床研究中心，临床营养研究单位，NIH支持的K30临床研究课程奖，以及公共卫生计划的科学硕士学位。本申请得到了儿科、内科、预防医学和丹佛儿童医院的支持。通过临床科学计划，提供统计学，流行病学，研究方法，伦理学和人类研究，医学写作，生物化学，药代动力学和分子生物学法规以及人类医学遗传学和分子遗传学方面的强大教学课程的能力，与BDC和UCHSC强大的指导教师相结合，将使我们能够为年轻的儿科医生提供持续的培训和发展。内分泌学家通过培训和发展成为独立的研究者，能够竞争独立的研究资金和研究活动。UCHSC内的其他计划将支持该计划，包括人类遗传学计划，免疫耐受网络和自身免疫预防中心。