K12 Career Development

K12职业发展

• 批准号: 8260907
• 负责人: GEORGEANNA J KLINGENSMITH
• 金额: $ 20.29万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8260907
• 关键词: Address; Adult; Area; Autoimmune Process; Autoimmunity; Basic Science; Behavioral Research; Biochemical; Biochemistry; Cell physiology; Center for Translational Science Activities; Childhood; Cities; Clinical; Clinical Research; Clinical Sciences; Colorado; Country; Diabetes Mellitus; Doctor of Philosophy; Drug Kinetics; Endocrinologist; Epidemic; Epidemiologic Studies; Epidemiology; Ethics; Faculty; Functional disorder; Funding; Genetic; Healthcare; Human; Human Genetics; Immune Tolerance; Immunobiology; Immunology; Insulin-Dependent Diabetes Mellitus; Investigation; Islet Cell; Master of Science; Medical; Medical Genetics; Medical Research; Medicine; Mentors; Molecular Biology; Molecular Genetics; Names; Non-Insulin-Dependent Diabetes Mellitus; Pediatric Hospitals; Physicians; Population; Prevention; Public Health; Public Health Schools; Published Comment; Regulation; Research; Research Institute; Research Methodology; Research Personnel; Research Training; Role; SECTM1 gene; Scientist; Training; Translational Research; United States National Institutes of Health; Universities; Work; Writing; career development; design; experience; health economics; improved; medical schools; multidisciplinary; next generation; pediatric department; programs; statistics; type I and type II diabetes

DESCRIPTION (provided by applicant): This application is a proposal for a career development program for pediatric endocrinologists, designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC), The University of Colorado School of Medicine (UC SOM) and the wider Anschutz Medical Campus (AMC). The proposal's rationale is: 1) there is a critical shortage of pediatric endocrinologists in the country, particuarly those trained and experienced in type 1 diabetes research 2) Diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economics viewpoint 3) Current rapid advances in diabetes investigation calls for an increased pool of physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out basic and translational research in pediatric type 1 and type 2 diabetes to bring advances in diabetes research to the clinical arena. The Barbara Davis Center has extensive and a proven record in research training of young investigators. The BDC and AMC have a well -established network of investigators working in the epidemiology, immunobiology, genetics, and molecular biology of type 1 diabetes, as well as the abnormal pathophysiology of type 2 diabetes. This network of experienced mentors is ideally suited to develop the next generation of young pediatric endocrinologists into independent diabetes investigators in high impact type 1 diabetes research. Areas of research focus within The Barbara Davis Center include islet cell physiology, genetics, molecular biology, immunology, the autoimmunity, prediction and prevention of type 1 diabetes, and the epidemiology, prevention and improved treatment of type 1 and type 2 diabetes. These areas of research are urgently needed and have been identified as important to the national public health to address the epidemic of diabetes in the US. This application is enhanced by the NIH supported Colorado Clinical and Translational Research Institute (CCTSI), Pediatric and Adult Clinical Translational Research Centers, as well as a strong Masters of Science in Public Health Program and in Clinical Science and PhD programs in the Colorado School of Public Health (CSPH) and within the CCTSI. This application has the support of the Departments of Pediatrics, Medicine, The CSPH, and The Children's Hospital of Denver. The ability to provide strong didactic coursework in statistics, epidemiology, research methods, ethics and regulation of human research, medical writing, biochemistry, pharmacokinetics and molecular biology, as well as human medical genetics and molecular genetics through the CCTSI, the BDC, the Program in Human Genetics and the cSPH, combined with a strong mentoring faculty at the BDC and UCSOM will allow us to provide the career development for young pediatric endocrinologists producing independent investigators, capable of competing for funding in high quality diabetes research. Other programs within UC SOM that are supportive of this program include the Program in Human Genetics, The Immune Tolerance Network, the Autoimmune Prevention Center and Children's Hospital Research Institute. PERFORMANCE SITE(S) (organization, city, state) The University of Colorado Denver, Denver, Colorado The Barbara Davis Center for Childhood Diabetes, Denver, Colorado KEY PERSONNEL. Name: Klingensmith, Georgeanna Organization: Barbara Davis Center, University of Colorado Denver Role on Project: Program Director PUBLIC HEALTH RELEVANCE: Our NIDDK Career Development Program "Developing Pediatric Diabetes Investigators for the Future" will be conducted at the Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Anschutz Medical Campus. Our PRINCIPAL OBJECTIVE is to develop junior faculty in Pediatric Endocrinology into highly qualified physician scientists, who are well grounded in basic and translational science research skills required for advancing the field of knowledge in type 1 diabetes and are educated in collaborative and integrated approaches for translating basic discoveries in type 1 diabetes into opportunities for advancing clinical research and care. Our OVERALL GOAL is that after their training, our Scholars will have acquired the professional skills for productive academic research careers as independent investigators and will have the leadership capacity to make significant impacts in the field of type 1 diabetes.

描述（由申请人提供）：此申请是针对儿科内分泌学家的职业发展计划的提案，旨在在芭芭拉·戴维斯中心（BDC），科罗拉多大学医学院（UC SOM）和更广泛的ANSCHUTZ Medical Campus（AMC）的糖尿病研究中提供多学科培训。该提议的理由是：1）在该国的儿科内分泌学家存在严重短缺，特别是那些在1型糖尿病研究中受过培训和经验的人，糖尿病是越来越重大的医疗保健问题。生化，流行病学和行为研究对小儿1型和2型糖尿病进行基本和转化研究，以将糖尿病研究的进步带入临床领域。芭芭拉·戴维斯中心（Barbara Davis Center）在年轻研究人员的研究培训中拥有广泛的记录。 BDC和AMC在1型糖尿病的流行病学，免疫生物学，遗传学和分子生物学以及2型糖尿病的异常病理生理学方面具有完善的研究人员网络。这个经验丰富的导师网络非常适合将下一代年轻的小儿内分泌学家开发到高影响1型糖尿病研究中的独立糖尿病研究人员中。芭芭拉·戴维斯中心（Barbara Davis Center）内部的研究重点包括胰岛细胞生理学，遗传学，分子生物学，免疫学，1型糖尿病的自身免疫性，预测和预防，以及1型和2型糖尿病的流行病学，预防和改善治疗。迫切需要这些研究领域，并被认为对国家公共卫生很重要，以解决美国糖尿病的流行。 NIH支持的科罗拉多州临床和转化研究所（CCTSI），儿科和成人临床转化研究中心以及科罗拉多州公共卫生学院（CSPH）（CSPH）和CCTSI内的临床科学和博士学位计划的强大科学硕士以及在CCTSI中增强了这一应用。该申请得到了儿科，医学，CSPH和丹佛儿童医院的支持。在统计学，流行病学，研究方法，伦理学和监管人类研究，医学写作，生物化学，药代动力学和分子生物学以及人类的医学遗传学和分子遗传学的能力，通过CCTSI，BDC，BDC，与人类的遗传学结合，BDC的能力在人类的医学遗传学和分子遗传学中允许人类的遗传学以及强度的ccts ccts，cctsi和人类的分子遗传学结合，为年轻的儿科内分泌学家提供职业发展，生产独立研究人员，能够在高质量的糖尿病研究中竞争资金。支持该计划的UC SOM中的其他计划包括人类遗传学计划，免疫耐受性网络，自身免疫预防中心和儿童医院研究所。绩效网站（S）（组织，城市，州）科罗拉多大学丹佛分校，科罗拉多州丹佛，芭芭拉·戴维斯儿童糖尿病中心，丹佛，科罗拉多州关键人员。姓名：乔治亚纳组织克林史密斯组织：科罗拉多大学丹佛大学项目的芭芭拉·戴维斯中心（Barbara Davis Center） 公共卫生相关性：我们的NIDDK职业发展计划“为未来开发儿科糖尿病调查人员”将在科罗拉多大学医学院医学院的芭芭拉·戴维斯儿童糖尿病中心进行。我们的主要目的是将小儿内分泌学的初级教师发展成高素质的医师科学家，他们以基本和转化的科学研究技巧为基础，这些技能促进了1型糖尿病中知识领域的发展，并以协作和综合方法的教育，用于将1型糖尿病的基本发现转化为临床研究和临床研究的机会。我们的总体目标是，在他们的培训之后，我们的学者将以独立研究人员的身份获得生产性学术研究职业的专业技能，并具有在1型糖尿病领域产生重大影响的领导能力。