K12 Career Development

K12职业发展

• 批准号: 8260907
• 负责人: GEORGEANNA J KLINGENSMITH
• 金额: $ 20.29万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8260907
• 关键词: Address; Adult; Area; Autoimmune Process; Autoimmunity; Basic Science; Behavioral Research; Biochemical; Biochemistry; Cell physiology; Center for Translational Science Activities; Childhood; Cities; Clinical; Clinical Research; Clinical Sciences; Colorado; Country; Diabetes Mellitus; Doctor of Philosophy; Drug Kinetics; Endocrinologist; Epidemic; Epidemiologic Studies; Epidemiology; Ethics; Faculty; Functional disorder; Funding; Genetic; Healthcare; Human; Human Genetics; Immune Tolerance; Immunobiology; Immunology; Insulin-Dependent Diabetes Mellitus; Investigation; Islet Cell; Master of Science; Medical; Medical Genetics; Medical Research; Medicine; Mentors; Molecular Biology; Molecular Genetics; Names; Non-Insulin-Dependent Diabetes Mellitus; Pediatric Hospitals; Physicians; Population; Prevention; Public Health; Public Health Schools; Published Comment; Regulation; Research; Research Institute; Research Methodology; Research Personnel; Research Training; Role; SECTM1 gene; Scientist; Training; Translational Research; United States National Institutes of Health; Universities; Work; Writing; career development; design; experience; health economics; improved; medical schools; multidisciplinary; next generation; pediatric department; programs; statistics; type I and type II diabetes

DESCRIPTION (provided by applicant): This application is a proposal for a career development program for pediatric endocrinologists, designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC), The University of Colorado School of Medicine (UC SOM) and the wider Anschutz Medical Campus (AMC). The proposal's rationale is: 1) there is a critical shortage of pediatric endocrinologists in the country, particuarly those trained and experienced in type 1 diabetes research 2) Diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economics viewpoint 3) Current rapid advances in diabetes investigation calls for an increased pool of physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out basic and translational research in pediatric type 1 and type 2 diabetes to bring advances in diabetes research to the clinical arena. The Barbara Davis Center has extensive and a proven record in research training of young investigators. The BDC and AMC have a well -established network of investigators working in the epidemiology, immunobiology, genetics, and molecular biology of type 1 diabetes, as well as the abnormal pathophysiology of type 2 diabetes. This network of experienced mentors is ideally suited to develop the next generation of young pediatric endocrinologists into independent diabetes investigators in high impact type 1 diabetes research. Areas of research focus within The Barbara Davis Center include islet cell physiology, genetics, molecular biology, immunology, the autoimmunity, prediction and prevention of type 1 diabetes, and the epidemiology, prevention and improved treatment of type 1 and type 2 diabetes. These areas of research are urgently needed and have been identified as important to the national public health to address the epidemic of diabetes in the US. This application is enhanced by the NIH supported Colorado Clinical and Translational Research Institute (CCTSI), Pediatric and Adult Clinical Translational Research Centers, as well as a strong Masters of Science in Public Health Program and in Clinical Science and PhD programs in the Colorado School of Public Health (CSPH) and within the CCTSI. This application has the support of the Departments of Pediatrics, Medicine, The CSPH, and The Children's Hospital of Denver. The ability to provide strong didactic coursework in statistics, epidemiology, research methods, ethics and regulation of human research, medical writing, biochemistry, pharmacokinetics and molecular biology, as well as human medical genetics and molecular genetics through the CCTSI, the BDC, the Program in Human Genetics and the cSPH, combined with a strong mentoring faculty at the BDC and UCSOM will allow us to provide the career development for young pediatric endocrinologists producing independent investigators, capable of competing for funding in high quality diabetes research. Other programs within UC SOM that are supportive of this program include the Program in Human Genetics, The Immune Tolerance Network, the Autoimmune Prevention Center and Children's Hospital Research Institute. PERFORMANCE SITE(S) (organization, city, state) The University of Colorado Denver, Denver, Colorado The Barbara Davis Center for Childhood Diabetes, Denver, Colorado KEY PERSONNEL. Name: Klingensmith, Georgeanna Organization: Barbara Davis Center, University of Colorado Denver Role on Project: Program Director PUBLIC HEALTH RELEVANCE: Our NIDDK Career Development Program "Developing Pediatric Diabetes Investigators for the Future" will be conducted at the Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Anschutz Medical Campus. Our PRINCIPAL OBJECTIVE is to develop junior faculty in Pediatric Endocrinology into highly qualified physician scientists, who are well grounded in basic and translational science research skills required for advancing the field of knowledge in type 1 diabetes and are educated in collaborative and integrated approaches for translating basic discoveries in type 1 diabetes into opportunities for advancing clinical research and care. Our OVERALL GOAL is that after their training, our Scholars will have acquired the professional skills for productive academic research careers as independent investigators and will have the leadership capacity to make significant impacts in the field of type 1 diabetes.

描述（由申请人提供）：本申请是儿科内分泌学家职业发展计划的提案，旨在为芭芭拉戴维斯中心（BDC），科罗拉多大学医学院（UC SOM）和更广泛的安舒茨医学校园（AMC）提供糖尿病研究的多学科培训。该提案的理由是：1）该国儿科内分泌学家严重短缺，特别是那些在1型糖尿病研究中受过训练和有经验的儿科内分泌学家2）糖尿病是儿科人群中日益重要的医疗保健问题，从个人和健康经济学的角度来看具有破坏性后果3）糖尿病研究的当前快速进展要求增加在临床，生物化学，流行病学和行为学研究，开展儿童1型和2型糖尿病的基础和转化研究，将糖尿病研究的进展带到临床竞技场。芭芭拉·戴维斯中心在年轻研究人员的研究培训方面有着广泛和可靠的记录。BDC和AMC有一个完善的研究人员网络，从事1型糖尿病的流行病学、免疫生物学、遗传学和分子生物学以及2型糖尿病的异常病理生理学研究。这个由经验丰富的导师组成的网络非常适合将下一代年轻的儿科内分泌学家培养成独立的糖尿病研究者，从事高影响力的1型糖尿病研究。芭芭拉戴维斯中心的研究重点领域包括胰岛细胞生理学，遗传学，分子生物学，免疫学，自身免疫，1型糖尿病的预测和预防，以及1型和2型糖尿病的流行病学，预防和改善治疗。这些领域的研究是迫切需要的，并已被确定为重要的国家公共卫生，以解决糖尿病在美国的流行。该应用程序得到了NIH支持的科罗拉多临床和转化研究所（CCTSI），儿科和成人临床转化研究中心以及科罗拉多公共卫生学院（CSPH）和CCTSI内的公共卫生计划和临床科学和博士课程的强大硕士学位的增强。此应用程序得到了儿科，医学，CSPH和丹佛儿童医院部门的支持。提供统计学，流行病学，研究方法，伦理学和人类研究，医学写作，生物化学，药代动力学和分子生物学法规的强大教学课程的能力，以及通过CCTSI，BDC，人类遗传学计划和cSPH的人类医学遗传学和分子遗传学，与BDC和UCSOM强大的指导教师相结合，将使我们能够为年轻的儿科内分泌学家提供职业发展，培养独立的研究人员，有能力在高质量的糖尿病研究中竞争资金。加州大学SOM内支持该计划的其他计划包括人类遗传学计划、免疫耐受网络、自身免疫预防中心和儿童医院研究所。执行地点（组织、城市、州）科罗拉多大学丹佛分校，丹佛，科罗拉多芭芭拉戴维斯儿童糖尿病中心，丹佛，科罗拉多关键人员。姓名：Klingensmith，Georgeanna组织：科罗拉多丹佛大学芭芭拉戴维斯中心项目角色：项目总监 公共卫生相关性：我们的NIDDK职业发展计划“为未来发展儿科糖尿病研究者”将在科罗拉多大学医学院安舒茨医学院芭芭拉戴维斯儿童糖尿病中心进行。我们的主要目标是将儿科内分泌学的初级教师培养成高素质的医生科学家，他们在推进1型糖尿病知识领域所需的基础和转化科学研究技能方面有很好的基础，并在将1型糖尿病的基本发现转化为推进临床研究和护理的机会的协作和综合方法中接受教育。我们的总体目标是，经过培训，我们的学者将获得专业技能，作为独立调查人员从事富有成效的学术研究，并将具有领导能力，在1型糖尿病领域产生重大影响。