K12 Career Development

K12职业发展

• 批准号: 8911299
• 负责人: GEORGEANNA J KLINGENSMITH
• 金额: $ 36.86万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8911299
• 关键词: Address; Adult; Area; Autoimmune Process; Autoimmunity; Basic Science; Behavioral Research; Biochemical; Biochemistry; Cell physiology; Center for Translational Science Activities; Childhood; Cities; Clinical; Clinical Research; Clinical Sciences; Colorado; Country; Diabetes Mellitus; Doctor of Philosophy; Drug Kinetics; Endocrinologist; Epidemic; Epidemiologic Studies; Epidemiology; Ethics; Faculty; Functional disorder; Funding; Genetic; Healthcare; Human; Human Genetics; Immune Tolerance; Immunobiology; Immunology; Insulin-Dependent Diabetes Mellitus; Investigation; Islet Cell; Master of Science; Medical; Medical Genetics; Medical Research; Medicine; Mentors; Molecular Biology; Molecular Genetics; Names; Non-Insulin-Dependent Diabetes Mellitus; Pediatric Hospitals; Physicians; Population; Prevention; Public Health; Public Health Schools; Published Comment; Regulation; Research; Research Institute; Research Methodology; Research Personnel; Research Training; Role; SECTM1 gene; Scientist; Training; Translational Research; United States National Institutes of Health; Universities; Work; Writing; career development; design; experience; health economics; improved; medical schools; multidisciplinary; next generation; pediatric department; programs; statistics; type I and type II diabetes

DESCRIPTION (provided by applicant): This application is a proposal for a career development program for pediatric endocrinologists, designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC), The University of Colorado School of Medicine (UC SOM) and the wider Anschutz Medical Campus (AMC). The proposal's rationale is: 1) there is a critical shortage of pediatric endocrinologists in the country, particuarly those trained and experienced in type 1 diabetes research 2) Diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economics viewpoint 3) Current rapid advances in diabetes investigation calls for an increased pool of physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out basic and translational research in pediatric type 1 and type 2 diabetes to bring advances in diabetes research to the clinical arena. The Barbara Davis Center has extensive and a proven record in research training of young investigators. The BDC and AMC have a well -established network of investigators working in the epidemiology, immunobiology, genetics, and molecular biology of type 1 diabetes, as well as the abnormal pathophysiology of type 2 diabetes. This network of experienced mentors is ideally suited to develop the next generation of young pediatric endocrinologists into independent diabetes investigators in high impact type 1 diabetes research. Areas of research focus within The Barbara Davis Center include islet cell physiology, genetics, molecular biology, immunology, the autoimmunity, prediction and prevention of type 1 diabetes, and the epidemiology, prevention and improved treatment of type 1 and type 2 diabetes. These areas of research are urgently needed and have been identified as important to the national public health to address the epidemic of diabetes in the US. This application is enhanced by the NIH supported Colorado Clinical and Translational Research Institute (CCTSI), Pediatric and Adult Clinical Translational Research Centers, as well as a strong Masters of Science in Public Health Program and in Clinical Science and PhD programs in the Colorado School of Public Health (CSPH) and within the CCTSI. This application has the support of the Departments of Pediatrics, Medicine, The CSPH, and The Children's Hospital of Denver. The ability to provide strong didactic coursework in statistics, epidemiology, research methods, ethics and regulation of human research, medical writing, biochemistry, pharmacokinetics and molecular biology, as well as human medical genetics and molecular genetics through the CCTSI, the BDC, the Program in Human Genetics and the cSPH, combined with a strong mentoring faculty at the BDC and UCSOM will allow us to provide the career development for young pediatric endocrinologists producing independent investigators, capable of competing for funding in high quality diabetes research. Other programs within UC SOM that are supportive of this program include the Program in Human Genetics, The Immune Tolerance Network, the Autoimmune Prevention Center and Children's Hospital Research Institute. PERFORMANCE SITE(S) (organization, city, state) The University of Colorado Denver, Denver, Colorado The Barbara Davis Center for Childhood Diabetes, Denver, Colorado KEY PERSONNEL. Name: Klingensmith, Georgeanna Organization: Barbara Davis Center, University of Colorado Denver Role on Project: Program Director

描述(由申请人提供)：本申请是针对儿科内分泌学家的职业发展计划的建议，旨在为芭芭拉·戴维斯中心(BDC)、科罗拉多大学医学院(UC SOM)和更广泛的安舒茨医学院(AMC)提供糖尿病研究方面的多学科培训。这项建议的基本理由是：1)国家严重缺乏儿科内分泌学家，尤其是那些在1型糖尿病研究方面训练有素和经验丰富的人。2)糖尿病是儿科人群中日益严重的医疗问题，从个人和健康经济学的角度来看，它带来了毁灭性的后果。3)当前糖尿病调查的快速发展要求更多受过临床、生化、流行病学和行为研究培训的内科科学家，以开展儿科1型和2型糖尿病的基础和转化研究，将糖尿病研究的进展带到临床舞台上。芭芭拉·戴维斯中心在年轻研究人员的研究培训方面拥有广泛和可靠的记录。BDC和AMC拥有完善的研究网络，研究1型糖尿病的流行病学、免疫生物学、遗传学和分子生物学，以及2型糖尿病的异常病理生理。这一经验丰富的导师网络非常适合将下一代年轻的儿科内分泌学家培养成高影响力的1型糖尿病研究中的独立糖尿病研究者。芭芭拉·戴维斯中心的研究重点领域包括胰岛细胞生理学、遗传学、分子生物学、免疫学、1型糖尿病的自身免疫、预测和预防，以及1型和2型糖尿病的流行病学、预防和改进治疗。这些领域的研究是迫切需要的，并已被确定为对国家公共卫生的重要，以解决美国的糖尿病流行问题。NIH支持的科罗拉多州临床和转化研究所(CCTSI)、儿科和成人临床转化研究中心，以及科罗拉多州公共卫生学院(CSPH)和CCTSI内强大的公共卫生科学硕士项目和临床科学和博士项目，都加强了这一申请。这项申请得到了儿科、内科、CSPH和丹佛儿童医院的支持。通过CCTSI、BDC、人类遗传学项目和CSPH提供强大的统计学、流行病学、研究方法、伦理学和人类研究监管、医学写作、生物化学、药代动力学和分子生物学以及人类医学遗传学和分子遗传学方面的强大教学课程的能力，加上BDC和UCSOM强大的指导教师队伍，将使我们能够为年轻的儿科内分泌学家提供职业发展，这些年轻的儿科内分泌学家产生独立的研究人员，能够竞争高质量糖尿病研究的资金。加州大学圣迭戈分校SOM内支持该计划的其他计划包括人类遗传学计划、免疫耐受网络、自身免疫预防中心和儿童医院研究所。演出现场(S)(组织、市、州)科罗拉多大学丹佛分校科罗拉多州丹佛市芭芭拉·戴维斯儿童糖尿病中心主要工作人员。姓名：乔治安娜大学克林根史密斯组织：科罗拉多大学丹佛分校芭芭拉·戴维斯中心项目职责：项目主管