Training Program in Diabetes Research

糖尿病研究培训计划

• 批准号: 7689440
• 负责人: GEORGEANNA J KLINGENSMITH
• 金额: $ 3.13万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7689440
• 关键词: Diabetes Mellitus; Research; Training Programs

DESCRIPTION (provided by applicant): This application is a renewal application for the training of pediatric endocrinology fellows in state of the art diabetes research. This training program is designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC) and The University of Colorado School of Medicine (UCSOM). The proposal's rationale is: 1) there is a critical shortage of pediatric endocrinologists in the country, particularly those trained and experienced in diabetes research 2) Diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economic point of view into the future 3) Current rapid advances in diabetes investigation calls for an increased pool of highly skilled physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out relevant, high quality basic and clinical translational research in pediatric type 1 and type 2 diabetes to bring advances in diabetes research to the clinical arena. The Barbara Davis Center has an extensive and a proven record in research training of young investigators. The BDC and UCSOM have a well established network of investigators working in the immunobiology, genetics, and molecular biology of type 1 diabetes, as well as the abnormal pathophysiology of type 2 diabetes. This network of experienced mentors is ideally suited to develop the next generation of young pediatric endocrinologists into independent diabetes investigators. Areas of research focus within The Barbara Davis Center include islet cell physiology, genetics, molecular biology, transplant immunology, and the autoimmunity, prediction and prevention of type 1 diabetes, as well as the epidemiology, prevention and treatment of type 1 and type 2 diabetes. These areas of research are urgently needed and have been identified as important to the national public health to address the epidemic of diabetes in the U.S. This application is enhanced by the NIH supported Diabetes and Endocrinology Research Center, well established, NIH supported Pediatric and Adult Clinical Translational Research Centers, and a Clinical Nutrition Research Unit, an NIH supported K30 Clinical Scientist Curriculum Award, as well as a strong Masters of Science in Public Health Program. This application has the support of the Departments of Pediatrics, Medicine, Preventive Medicine and The Children's Hospital of Denver (TCH). In the initial four years of our Training Program we have shown our ability to provide strong didactic coursework in statistics, epidemiology, research methods, ethics and regulation of human research, medical writing, biochemistry, pharmacokinetics and molecular biology through the Program in Clinical Science, as well as human medical genetics and molecular genetics, including genomics, proteomics, and metabolomics through the Program in Human Genetics. This didactic program combined with the strong mentoring faculty at the BDC and UCSOM has and will continue to allow us to provide the training young pediatric endocrinologists require to develop into independent investigators, capable of being competitive for independent research funding. The success of our graduates to secure NIH and JDRF individual mentored awards and faculty positions in academic centers, and our ability to attract excellent trainees with a clear commitment to academic research careers indicates the strength of the BDC in training pediatric endocrinologists in diabetes research. Programs within UCSOM which will be supportive of the program include The Immune Tolerance Network, the Autoimmune Prevention Center and TCH Research Foundation.

描述（由申请人提供）： 该应用程序是在最先进的糖尿病研究中培训儿科内分泌研究员的续签应用程序。该培训计划旨在在芭芭拉·戴维斯中心（BDC）和科罗拉多大学医学院（UCSOM）的糖尿病研究中提供多学科培训。该提议的理由是：1）在该国的小儿内分泌学家的严重短缺，尤其是那些在糖尿病研究中受过培训和经验的人，糖尿病是一个越来越重大的医疗保健问题，在小儿人群中，在糖尿病的个人和健康经济方面，临床的临时型越来越多地造成糖尿病的临时性，糖尿病的临时性越来越多3）造成的后果3）生化，流行病学和行为研究，以对1型和2型糖尿病进行相关的，高质量的基本和临床转化研究，以将糖尿病研究的进步带入临床领域。芭芭拉·戴维斯中心（Barbara Davis Center）在年轻调查人员的研究培训中拥有广泛的记录。 BDC和UCSOM具有1型糖尿病的免疫生物学，遗传学和分子生物学的研究人员网络，以及2型糖尿病的异常病理生理学。这个经验丰富的导师网络非常适合将下一代年轻的儿科内分泌学家发展成为独立的糖尿病研究人员。芭芭拉·戴维斯中心（Barbara Davis Center）内部的研究重点包括胰岛细胞生理学，遗传学，分子生物学，移植免疫学以及1型糖尿病的自身免疫性，预测和预防，以及1型和2型糖尿病的流行病学，预防和治疗。 These areas of research are urgently needed and have been identified as important to the national public health to address the epidemic of diabetes in the U.S. This application is enhanced by the NIH supported Diabetes and Endocrinology Research Center, well established, NIH supported Pediatric and Adult Clinical Translational Research Centers, and a Clinical Nutrition Research Unit, an NIH supported K30 Clinical Scientist Curriculum Award, as well as a strong Masters of Science in Public健康计划。该申请得到了儿科，医学，预防医学和丹佛儿童医院（TCH）的支持。在我们的培训计划的最初四年中，我们表明了我们在统计学，流行病学，研究方法，伦理学和人类研究，医学写作，生物化学，药代动力学和分子生物学的强大教学课程方面，以及人类医学遗传学和分子遗传学，包括人类遗传学，包括人类遗传学，以及概述，包括人类基因学，以及对人类遗传学的培训，并在内。这个教学计划结合了BDC和UCSOM的强大指导学院，并将继续使我们能够为年轻的儿科内分泌学家提供培训，以发展为独立研究人员，能够为独立研究提供竞争力。我们毕业生确保NIH和JDRF个人在学术中心获得奖项和教职员工职位的成功，以及我们对学术研究职业的明确承诺吸引出色的学员的能力，这表明BDC在培训糖尿病研究的儿科内分泌学家方面具有力量。 UCSOM中支持该计划的计划包括免疫耐受性网络，自身免疫预防中心和TCH研究基金会。