Training Program in Diabetes Research

糖尿病研究培训计划

• 批准号: 7689440
• 负责人: GEORGEANNA J KLINGENSMITH
• 金额: $ 3.13万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7689440
• 关键词: Diabetes Mellitus; Research; Training Programs

DESCRIPTION (provided by applicant): This application is a renewal application for the training of pediatric endocrinology fellows in state of the art diabetes research. This training program is designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC) and The University of Colorado School of Medicine (UCSOM). The proposal's rationale is: 1) there is a critical shortage of pediatric endocrinologists in the country, particularly those trained and experienced in diabetes research 2) Diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economic point of view into the future 3) Current rapid advances in diabetes investigation calls for an increased pool of highly skilled physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out relevant, high quality basic and clinical translational research in pediatric type 1 and type 2 diabetes to bring advances in diabetes research to the clinical arena. The Barbara Davis Center has an extensive and a proven record in research training of young investigators. The BDC and UCSOM have a well established network of investigators working in the immunobiology, genetics, and molecular biology of type 1 diabetes, as well as the abnormal pathophysiology of type 2 diabetes. This network of experienced mentors is ideally suited to develop the next generation of young pediatric endocrinologists into independent diabetes investigators. Areas of research focus within The Barbara Davis Center include islet cell physiology, genetics, molecular biology, transplant immunology, and the autoimmunity, prediction and prevention of type 1 diabetes, as well as the epidemiology, prevention and treatment of type 1 and type 2 diabetes. These areas of research are urgently needed and have been identified as important to the national public health to address the epidemic of diabetes in the U.S. This application is enhanced by the NIH supported Diabetes and Endocrinology Research Center, well established, NIH supported Pediatric and Adult Clinical Translational Research Centers, and a Clinical Nutrition Research Unit, an NIH supported K30 Clinical Scientist Curriculum Award, as well as a strong Masters of Science in Public Health Program. This application has the support of the Departments of Pediatrics, Medicine, Preventive Medicine and The Children's Hospital of Denver (TCH). In the initial four years of our Training Program we have shown our ability to provide strong didactic coursework in statistics, epidemiology, research methods, ethics and regulation of human research, medical writing, biochemistry, pharmacokinetics and molecular biology through the Program in Clinical Science, as well as human medical genetics and molecular genetics, including genomics, proteomics, and metabolomics through the Program in Human Genetics. This didactic program combined with the strong mentoring faculty at the BDC and UCSOM has and will continue to allow us to provide the training young pediatric endocrinologists require to develop into independent investigators, capable of being competitive for independent research funding. The success of our graduates to secure NIH and JDRF individual mentored awards and faculty positions in academic centers, and our ability to attract excellent trainees with a clear commitment to academic research careers indicates the strength of the BDC in training pediatric endocrinologists in diabetes research. Programs within UCSOM which will be supportive of the program include The Immune Tolerance Network, the Autoimmune Prevention Center and TCH Research Foundation.

描述（由申请人提供）： 此申请是一个更新的应用程序的培训儿科内分泌研究员在国家的最先进的糖尿病研究。该培训计划旨在为芭芭拉戴维斯中心（BDC）和科罗拉多大学医学院（UCSOM）提供糖尿病研究的多学科培训。该提案的理由是：1）该国儿科内分泌学家严重短缺，特别是那些在糖尿病研究方面受过训练和有经验的人2）糖尿病是儿科人群中日益重要的医疗保健问题，从个人和健康经济学的角度来看，未来会产生毁灭性的后果3）目前糖尿病研究的快速进展要求增加在临床、生物化学、流行病学，和行为研究，在儿童1型和2型糖尿病中开展相关的高质量基础和临床转化研究，将糖尿病研究的进展带到临床竞技场。芭芭拉·戴维斯中心在年轻研究人员的研究培训方面有着广泛和可靠的记录。BDC和UCSOM拥有完善的研究人员网络，致力于1型糖尿病的免疫生物学，遗传学和分子生物学，以及2型糖尿病的异常病理生理学。这个由经验丰富的导师组成的网络非常适合将下一代年轻的儿科内分泌学家培养成独立的糖尿病研究者。芭芭拉戴维斯中心的研究重点领域包括胰岛细胞生理学，遗传学，分子生物学，移植免疫学和自身免疫，预测和预防1型糖尿病，以及流行病学，预防和治疗1型和2型糖尿病。这些领域的研究是迫切需要的，并已被确定为重要的国家公共卫生，以解决糖尿病在美国的流行这一应用是由美国国立卫生研究院支持的糖尿病和内分泌研究中心，完善，美国国立卫生研究院支持的儿科和成人临床转化研究中心，和临床营养研究单位，美国国立卫生研究院支持的K30临床科学家课程奖，以及一个强大的公共卫生科学硕士项目。该应用程序得到了儿科，医学，预防医学和丹佛儿童医院（TCH）的支持。在我们的培训计划的最初四年，我们已经证明了我们有能力通过临床科学计划提供统计学，流行病学，研究方法，伦理学和人类研究，医学写作，生物化学，药代动力学和分子生物学监管方面的强有力的教学课程，以及人类医学遗传学和分子遗传学，包括基因组学，蛋白质组学和代谢组学通过人类遗传学计划。这个教学计划与BDC和UCSOM强大的指导教师相结合，已经并将继续使我们能够提供年轻的儿科内分泌学家发展成为独立研究者所需的培训，能够竞争独立的研究资金。我们的毕业生成功地获得了NIH和JDRF个人指导奖和学术中心的教师职位，以及我们吸引优秀学员并明确致力于学术研究事业的能力，表明了BDC在糖尿病研究中培训儿科内分泌学家的实力。UCSOM内将支持该计划的计划包括免疫耐受网络，自身免疫预防中心和TCH研究基金会。