Force Transmission in the Central Nervous System

中枢神经系统的力传递

• 批准号: 6526482
• 负责人: DAVID F MEANEY
• 金额: $ 63.67万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-03 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6526482
• 关键词: apoptosis; biophysics; brain injury; brain mapping; cerebral cortex; disease /disorder etiology; gene expression; immunocytochemistry; laboratory mouse; molecular pathology; protein metabolism

Description: The proposed project will bring together a broad team of bioengineers, neuroscientists, molecular biologists, bioinformaticists and clinical scientists to examine the molecular etiology of traumatic brain injury (TBI). The focus will be to study the genomic and protein expression of force transmission in the CNS, with the long term goal of treating and preventing neuronal necrosis and apoptosis in gray matter contusions, the most common form of damage in brain injured patients.

产品描述： 拟议中的项目将汇集一个广泛的生物工程师团队， 神经科学家、分子生物学家、生物信息学家和临床 科学家研究创伤性脑损伤（TBI）的分子病因。 重点将是研究力的基因组和蛋白质表达 中枢神经系统的传播，长期目标是治疗和预防 灰质挫伤中神经元坏死和凋亡， 脑损伤患者的损伤。