Metals in Medicine Gordon Research Conference

描述(由申请者提供)：请提供资金以支持与会者参加2002年7月和2004年7月在科尔比-索耶学院(新伦敦，NH)举行的金属医学戈登研究会议(MIM-GRC)。这款MIM-GRC是同类产品中的第一款。这是广受欢迎和享有盛誉的生物金属戈登研究会议(MIB-GRC)的自然延伸，该会议每年1月在加利福尼亚州文图拉举行。会议的目的有四个方面：*介绍对医学上具有重要意义的金属系统的最新研究，*确定新兴的研究机会领域，*加强学术界、政府和工业界科学家之间的交流，以及*促进该领域新的合作研究努力的形成。近年来，对金属在细胞调节中的作用、金属代谢的复杂性以及金属酶与遗传和环境疾病的关系的了解取得了重大进展。顺铂及其同系物的成功表明，金属络合物也可以被开发为治疗药物。开发成像和放射治疗药物的经验表明，金属络合物可以定制以提供临床上有用的药代动力学特性。MIM-GRC第一次会议要强调的议题是：(1)金属生成的自由基在健康和疾病中的作用；(2)金属蛋白质与健康和疾病；(3)作为药物靶标的金属蛋白质；(4)金属和金属络合物的运输；(5)磁共振成像剂；(6)金属离子、金属络合物和疟疾；(7)放射成像剂；(8)钒和铬与健康和疾病；(9)金属离子与核酸的相互作用。通过促进该领域蓬勃发展所需的许多跨学科互动，会议将在鼓励生物医学研究领域的新企业方面发挥关键作用。为了确保调查人员和方案的最佳组合，重要的是，参与费用不能成为受邀演讲者、讨论主席，特别是年轻和少数族裔与会者出席的限制因素。为支持MIMGRC所要求的少量资金将使组织者能够邀请和吸引参与者参与一个对健康科学的广泛领域产生影响的主题。

DESCRIPTION (provided by applicant): Funds are requested to support travel of participants to the Metals in Medicine Gordon Research Conference (MIM-GRC) to be held in July 2002 and July 2004 at Colby-Sawyer College (New London, NH). This MIM-GRC is the first of its kind. It is a natural extension of the popular and prestigious Metals in Biology Gordon Research Conference (MIB-GRC), which meets annually in January in Ventura, CA. The purpose of the conference is four-fold: * to present state-of-the-art research on metal-containing systems of medical importance, * to identify emerging areas of research opportunity, * to increase communication between scientists in academia, government, and industry, and * to foster the formation of new collaborative research efforts in the field.The understanding of the role of metals in cell regulation, the complexities of metal metabolism, and the relationship of metalloenzymes to genetic and environmental disease has seen major advances in recent years. The success of cisplatin and its congeners suggests that metal complexes can also be developed as therapeutic agents. Experience in the development of imaging and radiation therapy agents demonstrates that metal complexes can be tailored to provide clinically useful pharmacokinetic properties. The topics to be emphasized for the first MIM-GRC conference are (1) the role of metal-generated radicals in health and disease; (2) metalloproteins in health and disease; (3) metalloproteins as drug targets; (4) transport of metals and metal complexes; (5) magnetic resonance imaging agents; (6) metal ions, metal complexes and malaria; (7) radioimaging agents; (8) vanadium and chromium in health and disease and (9) metal ion-nucleic acid interactions. By facilitating the many interdisciplinary interactions necessary for this field to flourish the conference will play a key role in encouraging new enterprises in biomedical research. To ensure the best possible mix of investigators and programs, it is important that the cost of participation is not a limiting factor to the attendance of invited speakers, discussion chairs and, especially, young and minority attendees. The modest sum requested to support the MIMGRC will enable the organizers to invite and attract participants in a topic that has impact on a wide cross-section of health sciences.