Metals in Medicine Gordon Research Conference

描述（由申请人提供）：要求资金用于支持参与者参加于2002年7月和2004年7月在科尔比-索耶学院（新伦敦，新罕布什尔州）举行的医学金属戈登研究会议（MIM-GRC）。这是MIM-GRC的首创。它是受欢迎和享有声望的生物金属戈登研究会议（MIB-GRC）的自然延伸，该会议每年1月在加利福尼亚州文图拉举行。会议的目的有四个方面：*展示具有医学重要性的含金属系统的最新研究，*确定新兴的研究机会领域，*增加学术界、政府和工业界科学家之间的交流，并*促进该领域新的合作研究努力的形成。近年来，对金属在细胞调节中的作用、金属代谢的复杂性以及金属酶与遗传和环境疾病的关系的理解取得了重大进展。顺铂及其同系物的成功表明，金属配合物也可以开发为治疗剂。在成像和放射治疗剂的开发经验表明，金属配合物可以量身定制，以提供临床有用的药代动力学特性。第一届MIM-GRC会议要强调的主题是：(1)金属自由基在健康和疾病中的作用；(2)健康和疾病中的金属蛋白；(3)金属蛋白作为药物靶点；(4)金属和金属配合物的运输；(5)磁共振显像剂；（六）金属离子、金属配合物与疟疾；（七）放射显像剂；(8)钒铬在健康和疾病中的作用；(9)金属离子与核酸的相互作用。通过促进该领域蓬勃发展所必需的许多跨学科互动，会议将在鼓励生物医学研究的新企业方面发挥关键作用。为了确保研究人员和项目的最佳组合，重要的是，参与成本不应成为受邀演讲者，讨论主持人，特别是年轻人和少数民族与会者出席的限制因素。为支持MIMGRC请求的少量资金将使组织者能够邀请和吸引参与者参与对健康科学的广泛横截面产生影响的主题。

DESCRIPTION (provided by applicant): Funds are requested to support travel of participants to the Metals in Medicine Gordon Research Conference (MIM-GRC) to be held in July 2002 and July 2004 at Colby-Sawyer College (New London, NH). This MIM-GRC is the first of its kind. It is a natural extension of the popular and prestigious Metals in Biology Gordon Research Conference (MIB-GRC), which meets annually in January in Ventura, CA. The purpose of the conference is four-fold: * to present state-of-the-art research on metal-containing systems of medical importance, * to identify emerging areas of research opportunity, * to increase communication between scientists in academia, government, and industry, and * to foster the formation of new collaborative research efforts in the field.The understanding of the role of metals in cell regulation, the complexities of metal metabolism, and the relationship of metalloenzymes to genetic and environmental disease has seen major advances in recent years. The success of cisplatin and its congeners suggests that metal complexes can also be developed as therapeutic agents. Experience in the development of imaging and radiation therapy agents demonstrates that metal complexes can be tailored to provide clinically useful pharmacokinetic properties. The topics to be emphasized for the first MIM-GRC conference are (1) the role of metal-generated radicals in health and disease; (2) metalloproteins in health and disease; (3) metalloproteins as drug targets; (4) transport of metals and metal complexes; (5) magnetic resonance imaging agents; (6) metal ions, metal complexes and malaria; (7) radioimaging agents; (8) vanadium and chromium in health and disease and (9) metal ion-nucleic acid interactions. By facilitating the many interdisciplinary interactions necessary for this field to flourish the conference will play a key role in encouraging new enterprises in biomedical research. To ensure the best possible mix of investigators and programs, it is important that the cost of participation is not a limiting factor to the attendance of invited speakers, discussion chairs and, especially, young and minority attendees. The modest sum requested to support the MIMGRC will enable the organizers to invite and attract participants in a topic that has impact on a wide cross-section of health sciences.