Meiosis Gordon Conference

减数分裂戈登会议将于2002年6月16日至21日在新罕布夏州新伦敦的科尔比-索耶学院举行。这次会议将集中于旨在了解减数分裂机制的研究，减数分裂是二倍体生物产生单倍体配子的专门细胞分裂过程。减数分裂对有性生殖生物体至关重要，因为在减数分裂过程中染色体的精确分割对胚胎的正常发育和生存至关重要。未能正确执行减数分裂程序可能会导致染色体非整倍体，这是人类流产和出生缺陷的主要原因之一。此外，作为减数分裂程序组成部分的细胞过程，如遗传重组、姐妹染色单体凝聚和细胞周期检查点控制，对于维持体细胞基因组的完整性也是至关重要的。特别是，这些过程修复DNA损伤，防止染色体错误分离事件，否则可能导致癌症。因此，了解减数分裂和减数分裂染色体分离的控制对于确保人类胚胎的正常发育和预防肿瘤的发展具有重要意义。减数分裂戈登会议将为来自世界各地的140名科学家提供机会，讨论减数分裂领域的最新发展。大多数与会者是学术研究机构的首席研究员，但博士后研究员、研究生以及政府和工业实验室的成员也将参加。将有大约40-45名受邀演讲者，他们的演讲将涵盖模式生物和人类减数分裂的所有方面。将介绍一系列方法，包括细胞学、遗传学、细胞生物学和生化。全体会议将涉及减数分裂DNA复制和减数分裂重组的启动；减数分裂重组的途径、机制和调控；减数分裂前期的核重组、同源配对和联会；染色体凝聚、凝聚和减数分裂染色体轴；减数分裂着丝粒和染色体分离；会议和讲习班也将为科学讨论和思想交流提供机会。减数分裂戈登会议是仅有的两个定期举行的集中讨论减数分裂的会议之一。另一次会议每隔一年在欧洲举行，提供了一个更有限的参与机会，特别是对来自美国的科学家。因此，减数分裂戈登会议为提出和讨论有关有性繁殖和维持基因组完整性的核心过程的新发现提供了最重要的论坛。

The Meiosis Gordon Conference will be held from June 16-21, 2002 at Colby-Sawyer College in New London, New Hampshire. This conference will focus on research aimed at understanding the mechanisms of meiosis, the specialized cell division process by which diploid organisms generate haploid gametes. Meiosis is of central importance to sexually reproducing organisms, since precise partitioning of chromosomes during meiosis is critical for the normal development and viability of an embryo. Failure to execute the meiotic program correctly can lead to chromosomal aneuploidy, one of the leading causes of miscarriages and birth defects in humans. Further, cellular processes that are integral parts of the meiotic program, such as genetic recombination, sister chromatid cohesion, and cell-cycle checkpoint control, are also crucial for maintaining genome integrity in somatic cells. In particular, these processes repair DNA damage and prevent chromosome missegregation events that could otherwise lead to cancer. Thus understanding the control of meiosis and meiotic chromosome segregation is highly relevant both for efforts to ensure normal development of human embryos and to forestall the development of neoplasia. The Meiosis Gordon Conference will provide an opportunity for 140 scientists from throughout the world to meet and discuss the most recent developments in the meiosis field. Most attendees are principal investigators at academic research institutions, but postdoctoral fellows, graduate students and members of government and industrial laboratories will also attend. There will be about 40-45 invited speakers, whose lectures will cover all aspects of meiosis in model organisms as well as in humans. A range of approaches will be presented including cytology, genetics, cell biology and biochemistry. Plenary sessions will cover meiotic DNA replication and initiation of meiotic recombination; pathways, mechanisms and regulation of meiotic recombination; nuclear reorganization, homolog pairing and synapsis during meiotic prophase; chromosome condensation, cohesion and meiotic chromosome axes; meiotic centromeres and chromosome segregation; sessions and workshops will also provide opportunities for scientific discussion and exchange of ideas. The Meiosis Gordon Conference is one of only two regularly held meetings that concentrate on meiosis. The other meeting is held in alternate years in Europe and provides a more limited opportunity for participation, especially for scientists from the United States. The Meiosis Gordon Conference thus provides the most important forum for presenting and discussing new findings regarding a process that is central to sexual reproduction and to maintenance of genome integrity.