Meiotic Chromosome Inheritance in Caenorhabditis
Meiotic Chromosome Inheritance in Caenorhabditis
批准号:
10623710
负责人:
ANNE M VILLENEUVE
金额:
$80.8万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
未结题
起止时间:
2018-04-01 至 2028-03-31
关键词:
AneuploidyAreaBiochemicalCaenorhabditisCaenorhabditis elegansCellsChromosome PairingChromosome StructuresChromosomesCongenital AbnormalityCytologyDNA Double Strand BreakDNA RepairDevelopmentDiploidyDistantEnsureEquilibriumEventFailureGeneticGenetic Crossing OverGenomeGenomicsGerm CellsGoalsHaploidyHealthHomologous GeneHumanHybridsInvestigationMeiosisMeiotic RecombinationModelingMolecularNematodaOrganismPositioning AttributePreparationProcessPropertyProphaseResearchSpontaneous abortionSystemWorkgenome integritynovel strategiesprogramsrepairedsegregationspatial relationshipsuccesstumor progression
中文摘要
项目总结
英文摘要
Program Summary
Our research is aimed at understanding the molecular and cellular mechanisms underlying the faithful
inheritance eukaryotic chromosomes. Our primary focus is on elucidating the events required for the orderly
segregation of homologous chromosomes during meiosis, the crucial process by which diploid germ cells
generate haploid gametes. These events are of central importance to sexually reproducing organisms, since
failure to execute them correctly leads to chromosomal aneuploidy, one of the leading causes of miscarriages
and birth defects in humans. During meiotic prophase, chromosomes undergo a dramatic and dynamic program
of structural reorganization in preparation for the meiotic divisions. Moreover, chromosome inheritance during
meiosis relies on the formation of double-strand DNA breaks (DSBs) and repair of a subset of these DSBs as
inter-homolog crossovers (COs). Because the DSBs that serve as the initiating events of meiotic recombination
pose a danger to genome integrity, the success of genome inheritance during meiosis requires cells to maintain
a balance between the beneficial effects of COs and the potential harmful consequences of the process by which
they are generated. A major goal of our research is to understand the mechanisms that operate during meiosis
to achieve this crucial balance. An inter-related goal is to understand how meiosis-specific chromosome
organization is established, maintained, and remodeled to bring about successful segregation of homologous
chromosomes. We are approaching these issues using Caenorhabditis nematodes, simple metazoan organisms
that are especially amenable to an integrated application of powerful cytological, genetic, genomic, and
biochemical approaches, and in which the events under study are particularly accessible. Our goal under the
MIRA program is to pursue a systems-level understanding of meiosis, based on the recognition that multiple
distinct aspects of the meiotic program are intimately interconnected, and that robustness of the system is an
emergent property of this interconnectedness. Our approach will build on recent technical advances and new
discoveries in the well-established C. elegans experimental system, in combination with opportunities afforded
by a newly-introduced Caenorhabditis interspecies hybrid model, to interrogate the meiotic program at multiple
levels. Planned areas of investigation will include: Elucidating mechanisms that ensure reliable formation of CO-
based connections for all chromosome pairs; Exploring how different events and developmental transitions in
the meiotic program are temporally and spatially coordinated; Investigating the functional organization of
meiosis-specific chromosome structures that promote and regulate meiotic recombination and enable
chromosomes to sense and respond to events occurring at distant positions; Pursuing a new approach aimed at
understanding the fundamental basis of homolog recognition.
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会议论文
Meiotic Chromosome Inheritance in C. elegans
-
批准号:9901589
-
项目类别:
-
资助金额:$66.75万
-
财政年份:2018
-
负责人:ANNE M VILLENEUVE
-
依托单位:
Meiotic Chromosome Inheritance in C. elegans
-
批准号:10377335
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项目类别:
-
资助金额:$66.77万
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财政年份:2018
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负责人:ANNE M VILLENEUVE
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依托单位:
Genetic Recombination in C.elegans
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批准号:7993800
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项目类别:
-
资助金额:$9.11万
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财政年份:2010
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负责人:ANNE M VILLENEUVE
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依托单位:
CHROMATIN-ASSOCIATED PROTEIN COMPLEXES IN THE C ELEGANS GERM LINE
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批准号:7420800
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项目类别:
-
资助金额:$0.29万
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财政年份:2006
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负责人:ANNE M VILLENEUVE
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依托单位:
Genetic Recombination in C elegans
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批准号:6751214
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项目类别:
-
资助金额:$29.47万
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财政年份:2003
-
负责人:ANNE M VILLENEUVE
-
依托单位:
Genetic Recombination in C.elegans
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批准号:8054299
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项目类别:
-
资助金额:$30.97万
-
财政年份:2003
-
负责人:ANNE M VILLENEUVE
-
依托单位:
Genetic Recombination of c. Elegans
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批准号:8373771
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项目类别:
-
资助金额:$32.93万
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财政年份:2003
-
负责人:ANNE M VILLENEUVE
-
依托单位:
Genetic Recombination in C. elegans
-
批准号:9323509
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项目类别:
-
资助金额:$37.39万
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财政年份:2003
-
负责人:ANNE M VILLENEUVE
-
依托单位:
Genetic Recombination of c. Elegans
-
批准号:8523907
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项目类别:
-
资助金额:$31.78万
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财政年份:2003
-
负责人:ANNE M VILLENEUVE
-
依托单位:
Genetic Recombination in C. elegans
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批准号:9177624
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项目类别:
-
资助金额:$41.35万
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财政年份:2003
-
负责人:ANNE M VILLENEUVE
-
依托单位:
Genetic Recombination in C.elegans
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批准号:7596199
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项目类别:
-
资助金额:$30.93万
-
财政年份:2003
-
负责人:ANNE M VILLENEUVE
-
依托单位:
Genetic Recombination in C.elegans
-
批准号:7466963
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项目类别:
-
资助金额:$31.47万
-
财政年份:2003
-
负责人:ANNE M VILLENEUVE
-
依托单位:
Genetic Recombination in C elegans
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批准号:7071877
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项目类别:
-
资助金额:$28.77万
-
财政年份:2003
-
负责人:ANNE M VILLENEUVE
-
依托单位:
Genetic Recombination in C elegans
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批准号:6891029
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项目类别:
-
资助金额:$29.46万
-
财政年份:2003
-
负责人:ANNE M VILLENEUVE
-
依托单位:
Genetic Recombination of c. Elegans
-
批准号:8691863
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项目类别:
-
资助金额:$33.24万
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财政年份:2003
-
负责人:ANNE M VILLENEUVE
-
依托单位:
Genetic Recombination in C elegans
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批准号:6679660
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项目类别:
-
资助金额:$31.35万
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财政年份:2003
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负责人:ANNE M VILLENEUVE
-
依托单位:
Meiosis Gordon Conference
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批准号:6506608
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项目类别:
-
资助金额:$0.75万
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财政年份:2002
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负责人:ANNE M VILLENEUVE
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依托单位:
MEIOSIS GORDON CONFERENCE
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批准号:6158350
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项目类别:
-
资助金额:$0.6万
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财政年份:2000
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负责人:ANNE M VILLENEUVE
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依托单位:
MEIOTIC CHROMOSOME SEGREGATION IN C ELEGANS
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批准号:2332022
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项目类别:
-
资助金额:$19.75万
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财政年份:1996
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负责人:ANNE M VILLENEUVE
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依托单位:
CHROMOSOME SEGREGATION IN CAENORHABDITIS ELEGANS
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批准号:6286232
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项目类别:
-
资助金额:$29.81万
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财政年份:1996
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负责人:ANNE M VILLENEUVE
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依托单位:
国内基金
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层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
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批准年份:1988
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