Comparison of Microbiologic and Cytologic Results for Bronchoalveolar Lavages

支气管肺泡灌洗的微生物学和细胞学结果的比较

• 批准号: 6103707
• 负责人: Frank G Witebsky
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6103707
• 关键词: Mycobacterium tuberculosis; Pneumocystis carinii; clinical research; communicable disease diagnosis; cytology; diagnosis design /evaluation; diagnostic respiratory lavage; human tissue; microbiology; respiratory disorder

Bronchoalveolar lavage (BAL) specimens are usually split between cytology and microbiology. As different methodologies are used by these two laboratories in the work-up of these specimens, we thought it would be useful to review the results obtained on these specimens by each laboratory. Such a review might help define the relative sensitivities of the different procedures employed, suggest areas of redundancy that might be candidates for elimination, and help identify the procedures most likely to produce clinically significant results. Preliminary results suggest that cytology preparations are more sensitive for the direct detection of significant fungal pathogens than the smears prepared in microbiology. This is presumably because of the larger volume of material used for preparation of smears in cytology. The data for approximately 7 years have been collected and are currently being analyzed to assess the relative sensitivities of the procedures performed in the two laboratories for the detection of other pathogens such as Mycobacterium tuberculosis and Pneumocystis carinii.

支气管肺泡灌洗（BAL）标本 通常分为细胞学和微生物学。为不同 这两个实验室在处理 这些标本，我们认为这将是有益的审查， 每个实验室对这些样本的检测结果。这样的 审查可能有助于确定不同的相对敏感性 所采用的程序，建议冗余的领域， 候选人的淘汰，并帮助确定程序最 可能产生临床显著结果。初步结果 表明细胞学制备对直接的 比制备的涂片检测显著的真菌病原体 微生物学这大概是因为体积较大的 在细胞学中用于制备涂片的材料。的数据 已经收集了大约7年，目前正在 分析以评估程序的相对灵敏度 在两个实验室进行的其他检测 结核分枝杆菌和肺孢子虫等病原体 carinii。