SUSCEPTIBILITY TESTING PROCEDURES FOR RAPIDLY GROWING MYCOBACTERIA AND NOCARDIA

对于快速生长的分枝杆菌或诺卡氏菌，目前还没有标准化的药敏试验程序.建议使用几种不同的程序，包括肉汤微量稀释和Etest（由AB Biodisk，卡尔弗城，CA生产）。Etest产生的结果难以解释这些微生物，我们目前不计划对这些微生物进行任何进一步的研究。我们是一项多机构研究的合作者，旨在确定Etest和微量稀释法用于快速生长分枝杆菌药敏试验的机构间和机构内重现性。已经分析了来自该研究的微量稀释程序的结果，并且结果已经发表（Woods GL等人，J. Clin.Microbiol. 1999;37：1676-1682）。微量稀释法有可能成为快速生长分枝杆菌药敏试验的参考方法。这个项目被终止了。

No standardized susceptibility testing procedures exist for rapidly- growing mycobacteria or Nocardia species. Several different procedures have been suggested for use, including broth microdilution and the Etest (manufactured by AB Biodisk, Culver City, CA). The Etest produces results which are difficult to interpret with these organisms, and we do not plan to do any further work with this procedure for these organisms at present. We were collaborators in a multi-institution study to determine the inter- and intra-institution reproducibility of both the Etest and a microdilution procedure for susceptibility testing of rapidly-growing mycobacteria. The results of the microdilution procedure from this study have been analyzed, and the results have been published (Woods GL, et al, J. Clin. Microbiol. 1999;37:1676-1682). The microdilution procedure employed will probably become the reference procedure for susceptibility testing of rapidly-growing mycobacteria. This project is terminated.