COOPERATIVE HUMAN TISSUE NETWORK EASTERN DIVISION

这一资源的广泛和长期目标是通过加强宾夕法尼亚大学的参与来满足癌症研究对组织标本日益增长的需求。宾夕法尼亚大学将专注于保持灵活的资源，能够快速发展，以应对不断变化的组织需求、新兴的研究技术和不断变化的监管环境；这将通过继续关注运营创新和技术调整来实现，以提高效率和效力。具体目标概括如下：(1)提供具有良好特征的恶性、正常和良性人体组织样本。采购和准备将由调查人员的需求驱动，并包括各种新兴技术。(2)通过一个综合计划确保ED组织、数据和服务的最高质量，该计划涵盖从最初的研究人员接收、方案制定、组织采购/运输到账单，最后是研究人员反馈的各个方面。(3)保护其组织和/或数据可能被CHTN研究人员使用的受试者的权利，并保护工作人员和研究人员的安全。(4)在整个网络中发挥重要的合作作用，利用教育署的独特经验和优势，通过结构和操作上的创新，提高网络对研究人员的有用性。人体组织为研究人类疾病提供了重要的模型，包括研究癌症的遗传异常和易感性。研究人员可以自由地将更多的时间集中在他们的研究上；诊断的质量控制可以防止错误的发现。方法将包括定制组织准备，如显微解剖、微阵列和DNA/RNA准备；质量措施，包括组织质量控制、工作人员培训计划、研究人员满意度监测、数据验证和语音识别软件，以提高效率；隐私措施，如去身份、知情同意和加密；利用信息学、营销和外联方面的优势，以及多媒体培训技术。

The broad, long-term objective of.this resource is to meet the increasing demand for tissue specimens for cancer research by enhancing the participation of the University of Pennsylvania (UPEND as the Eastern Division (ED) of the Cooperative Human Tissue Network (CHTN). UPENN will focus on maintaining a flexible resource capable of evolving rapidly in response to changing tissue needs, emerging research technologies, and shifting regulatory environments; this will be accomplished by a continuing focus on operational innovation and technological adaptation to improve efficiency and effectiveness. The specific aims are summarized as follows: (1) To provide a diversity of well-characterized malignant, normal, and benign human tissue samples. Sourcing and preparation will be driven by investigator needs and include various emerging technologies. (2) To assure the highest quality of ED tissue, data, and services through an integrated program that addresses every aspect, from initial researcher intake through protocol development to tissue procurement/shipment to billing and, finally, researcher feedback. (3) To protect the rights of human subjects whose tissue and/or data may be utilized by CHTN researchers and to protect the safety of staff and research personnel. (4) To play a key cooperative role in the CHTN as a whole, using the ED's unique experience and strengths to improve the network's usefulness to researchers through innovations in structure and operation. Human tissues provide an essential model for the study of human diseases, including research into genetic abnormalities and pre-dispositions in cancer. Researchers are free to focus more time on their research; quality control of diagnoses prevents erroneous findings. Methods will include custom tissue preparations like microdissection, microarray, and DNA/RNA preparation; quality measures including histologic quality control, staff training programs, researcher satisfaction monitoring, data verification, and voice recognition software to enhance efficiency; such privacy measures as de-identification, informed consent, and encryption; use of strengths in informatics, marketing and outreach, and multi-media training techniques.