COOPERATIVE HUMAN TISSUE NETWORK EASTERN DIVISION

人体组织合作网络东部分部

• 批准号: 6512401
• 负责人: VIRGINIA ANNE LIVOLSI
• 金额: $ 105.1万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-07 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6512401
• 关键词: cancer information system; cancer registry /resource; cooperative study; education evaluation /planning; histopathology; human tissue; microarray technology; neoplasm /cancer education; tissue resource /registry

The broad, long-term objective of.this resource is to meet the increasing demand for tissue specimens for cancer research by enhancing the participation of the University of Pennsylvania (UPEND as the Eastern Division (ED) of the Cooperative Human Tissue Network (CHTN). UPENN will focus on maintaining a flexible resource capable of evolving rapidly in response to changing tissue needs, emerging research technologies, and shifting regulatory environments; this will be accomplished by a continuing focus on operational innovation and technological adaptation to improve efficiency and effectiveness. The specific aims are summarized as follows: (1) To provide a diversity of well-characterized malignant, normal, and benign human tissue samples. Sourcing and preparation will be driven by investigator needs and include various emerging technologies. (2) To assure the highest quality of ED tissue, data, and services through an integrated program that addresses every aspect, from initial researcher intake through protocol development to tissue procurement/shipment to billing and, finally, researcher feedback. (3) To protect the rights of human subjects whose tissue and/or data may be utilized by CHTN researchers and to protect the safety of staff and research personnel. (4) To play a key cooperative role in the CHTN as a whole, using the ED's unique experience and strengths to improve the network's usefulness to researchers through innovations in structure and operation. Human tissues provide an essential model for the study of human diseases, including research into genetic abnormalities and pre-dispositions in cancer. Researchers are free to focus more time on their research; quality control of diagnoses prevents erroneous findings. Methods will include custom tissue preparations like microdissection, microarray, and DNA/RNA preparation; quality measures including histologic quality control, staff training programs, researcher satisfaction monitoring, data verification, and voice recognition software to enhance efficiency; such privacy measures as de-identification, informed consent, and encryption; use of strengths in informatics, marketing and outreach, and multi-media training techniques.

该资源的广泛的长期目标是通过加强宾夕法尼亚大学（UPEND）作为合作人类组织网络（CHTN）的东部分部（艾德）的参与，满足癌症研究对组织标本日益增长的需求。UPENN将专注于保持一个灵活的资源，能够迅速发展，以应对不断变化的组织需求，新兴的研究技术和不断变化的监管环境;这将通过持续关注业务创新和技术适应来实现，以提高效率和有效性。具体目标总结如下：（1）提供多种特征明确的恶性、正常和良性人体组织样本。采购和准备将由研究者需求驱动，并包括各种新兴技术。(2)通过一个综合计划确保艾德组织、数据和服务的最高质量，该计划涉及各个方面，从最初的研究人员摄入到方案制定，到组织采购/运输，再到计费，最后是研究人员的反馈。(3)保护CHTN研究人员可能使用其组织和/或数据的人类受试者的权利，并保护工作人员和研究人员的安全。(4)发挥中心的重要合作作用，利用艾德的独特经验和优势，通过结构和运作的创新，提高网络对研究人员的有用性。人体组织是研究人类疾病的重要模型，包括研究遗传异常和癌症易感性。研究人员可以自由地将更多的时间集中在他们的研究上;诊断的质量控制可以防止错误的发现。方法将包括定制组织制备，如显微切割，微阵列和DNA/RNA制备;质量措施，包括组织学质量控制，员工培训计划，研究人员满意度监测，数据验证和语音识别软件，以提高效率;隐私措施，如去识别，知情同意和加密;利用信息学，营销和推广以及多媒体培训技术的优势。