COOPERATIVE HUMAN TISSUE NETWORK EASTERN DIVISION

的广泛而长期的目标。该资源旨在通过加强宾夕法尼亚大学（UPEND）作为合作人体组织网络（CHTN）东部分部（ED）的参与，满足对癌症研究组织标本日益增长的需求。UPENN将专注于保持灵活的资源，能够快速发展，以响应不断变化的组织需求、新兴研究技术和不断变化的监管环境；这将通过继续注重业务创新和技术调整以提高效率和效力来实现。具体目的总结如下：(1)提供多种特征良好的恶性、正常和良性人体组织样本。采购和准备工作将由调查人员的需求驱动，并包括各种新兴技术。(2)通过一个综合项目来确保ED组织、数据和服务的最高质量，该项目涉及从最初的研究人员招募到协议制定到组织采购/运输到计费，最后到研究人员反馈的各个方面。(3)保护CHTN研究人员可能使用其组织和/或数据的人类受试者的权利，并保护工作人员和研究人员的安全。(4)利用教育局的独特经验和优势，通过结构和运营创新，提高网络对研究人员的有用性，在整个CHTN中发挥关键的合作作用。人体组织为研究人类疾病，包括研究遗传异常和癌症易感性提供了一个基本模型。研究人员可以自由地将更多的时间集中在他们的研究上；诊断的质量控制可以防止错误的发现。方法将包括定制组织制备，如显微解剖，微阵列和DNA/RNA制备；质量措施包括组织质量控制、员工培训计划、研究人员满意度监测、数据验证和语音识别软件，以提高效率；诸如去识别、知情同意和加密等隐私措施；运用信息学、市场营销和推广以及多媒体培训技术方面的优势。

The broad, long-term objective of.this resource is to meet the increasing demand for tissue specimens for cancer research by enhancing the participation of the University of Pennsylvania (UPEND as the Eastern Division (ED) of the Cooperative Human Tissue Network (CHTN). UPENN will focus on maintaining a flexible resource capable of evolving rapidly in response to changing tissue needs, emerging research technologies, and shifting regulatory environments; this will be accomplished by a continuing focus on operational innovation and technological adaptation to improve efficiency and effectiveness. The specific aims are summarized as follows: (1) To provide a diversity of well-characterized malignant, normal, and benign human tissue samples. Sourcing and preparation will be driven by investigator needs and include various emerging technologies. (2) To assure the highest quality of ED tissue, data, and services through an integrated program that addresses every aspect, from initial researcher intake through protocol development to tissue procurement/shipment to billing and, finally, researcher feedback. (3) To protect the rights of human subjects whose tissue and/or data may be utilized by CHTN researchers and to protect the safety of staff and research personnel. (4) To play a key cooperative role in the CHTN as a whole, using the ED's unique experience and strengths to improve the network's usefulness to researchers through innovations in structure and operation. Human tissues provide an essential model for the study of human diseases, including research into genetic abnormalities and pre-dispositions in cancer. Researchers are free to focus more time on their research; quality control of diagnoses prevents erroneous findings. Methods will include custom tissue preparations like microdissection, microarray, and DNA/RNA preparation; quality measures including histologic quality control, staff training programs, researcher satisfaction monitoring, data verification, and voice recognition software to enhance efficiency; such privacy measures as de-identification, informed consent, and encryption; use of strengths in informatics, marketing and outreach, and multi-media training techniques.