COOPERATIVE HUMAN TISSUE NETWORK EASTERN DIVISION

摘要：人体组织合作网络的核心使命是 向研究人员分发高质量、特征良好的人类生物标本， 人类疾病在过去的31年里，目前的东部赛区（艾德）已经建立了一个充满活力的 基础设施，并为研究社区带来了资源。这样做的目的 一个建议是传达艾德的优势和创新，并通过以下方式描述计划 已经成功的生物标本采购和分配资源将促进 并在未来5年周期内加强生物医学发现。宾夕法尼亚大学 （UPENN）作为目前的合作人体组织网络东部分部（艾德） （CHTN）.提交此申请，继续作为拟议网络的成人部门。到 为了支持这一目标，我们提出了以下艾德在此赠款期间的具体目标 周期1)为了通过业务创新提高该网络对调查人员的价值， 以便提供多样化的生物样品供应。为了满足客户的特殊要求， CHTN调查人员，通过使用有针对性的采购方法来收集标本。2)以确保 尽可能高质量的组织、数据和服务。要使用集成的IT基础架构， 监测和促进生物储存库的运作和服务（收集、加工、质量 控制、分发和存储），保证响应性、交互性资源， 新兴的科学趋势。3)通过传播 经过验证的、成功的研究者招募品牌和个性化的客户服务， 确保研究人员对资源的满意度。4)与其他成员合作， CHTN通过提高样本的可访问性， 部门之间的互操作性，并扩大对创新的调查， 方法和探索生物储藏科学的新途径。 艾德建议采用创新的方法来提高网络的实力， 保证分发生物标本的质量。

ABSTRACT: The core mission of the Cooperative Human Tissue Network has been the distribution of high quality, well-characterized human biospecimens to researchers who study human disease. Over the past 31 years, the current Eastern Division (ED) has built a dynamic infrastructure and has brought the resource to the research community. The purpose of this proposal is to convey the strengths and innovations of the ED and to describe the plan through which an already successful biospecimen procurement and distribution resource will facilitate and enhance biomedical discovery over the next 5 year cycle. The University of Pennsylvania (UPENN) as the current Eastern Division (ED) of the Cooperative Human Tissue Network (CHTN). submits this application to continue as an adult division of the proposed network. To support this objective, we present the following as specific aims of the ED during this grant cycle. 1) To improve the value of the Network to investigators through innovations in operations, in order to provide a diversified supply of biosamples. To fulfill the specialized requests of the CHTN investigators, by using a targeted sourcing approach to specimen collection. 2) To assure the highest possible quality of tissue, data and services. To use an integrated IT infrastructure to monitor and facilitate biorepository operations and services (collection, processing, quality control, distribution, and storage) guaranteeing a responsive, interactive resource that will adapt to emerging scientific trends. 3) To maximize the impact of the resource by disseminating a proven, successful brand of investigator recruitment and personalized customer service, ensuring researcher satisfaction with the resource. 4) To collaborate with other members of the CHTN to ensure an effective resource by enhancing accessibility to samples, harmonizing interoperability between divisions and by expanding investigations into innovative methodologies and exploring new avenues of biorepository sciences. The ED proposes to bring a innovative approach to improve the strength of the network and to guarantee quality of the distributed biospecimens.