COLLABORATIVE HUMAN TISSUE NETWORK EASTERN DIVISION

描述（由申请人提供）：合作人体组织网络的核心任务是向研究人类疾病的研究人员分发高质量、特征良好的人类生物标本。在过去的27年里，目前的东部分部（ED）建立了一个充满活力的基础设施，培训了一支敬业的员工队伍，并为研究界带来了资源。本提案的目的是传达ED的优势和创新，并描述计划，通过该计划，已经成功的生物标本采购和分发资源将在未来5年周期内促进和加强生物医学发现。宾夕法尼亚大学（UPENN）作为合作人体组织网络的当前东部分部（ED）提交此申请，以继续作为拟议的合作人体组织网络（CHTN）的成人分部。为达致上述目标，我们建议教育署在此拨款周期内的具体目标如下：1)通过业务创新提高网络对调查人员的价值，以提供多样化的生物样本供应。通过使用有针对性的采购方法来收集标本，以满足CHTN调查员的专业要求。2)确保组织、数据和服务的最高质量。使用集成的IT基础设施来监测和促进生物储存库的操作和服务（收集、处理、质量控制、分发和存储），确保具有响应性和互动性的资源

DESCRIPTION (provided by applicant): The core mission of the Cooperative Human Tissue Network has been the distribution of high quality, well-characterized human biospecimens to researchers who study human disease. Over the past 27 years, the current Eastern Division (ED) has built a dynamic infrastructure, has trained a dedicated staff, and has brought the resource to the research community. The purpose of this proposal is to convey the strengths and innovations of the ED and to describe the plan through which an already successful biospecimen procurement and distribution resource will facilitate and enhance biomedical discovery over the next 5 year cycle. The University of Pennsylvania (UPENN) as the current Eastern Division (ED) of the Cooperative Human Tissue Network submits this application to continue as an adult division of the proposed Collaborative Human Tissue Network (CHTN). To support this objective, we propose the following as specific aims of the ED during this grant cycle. 1) To improve the value of the Network to investigators through innovations in operations, in order to provide a diversified supply of biosamples. To fulfill the specialized requests of the CHTN investigators, by using a targeted sourcing approach to specimen collection. 2) To assure the highest possible quality of tissue, data and services. To use an integrated IT infrastructure t monitor and facilitate biorepository operations and services (collection, processing, quality control, distribution, and storage) guaranteeing a responsive, interactive resource that will adapt to emerging scientific trends. 3) To maximize the impact of the resource by disseminating a proven, successful brand of investigator recruitment and personalized customer service, ensuring researcher satisfaction with the resource. 4) To collaborate with other members of the CHTN to ensure an effective resource by enhancing accessibility to samples, harmonizing interoperability between divisions and by expanding investigations into innovative methodologies and exploring new avenues of biorepository sciences. The ED proposes to bring a unique and innovative procedural methodology to improve the strength of the network to guarantee quality of the distributed biospecimens.