COLLABORATIVE HUMAN TISSUE NETWORK EASTERN DIVISION

描述(由申请人提供)：合作人体组织网络的核心任务是向研究人类疾病的研究人员分发高质量、特征良好的人类生物标本。在过去的27年里，目前的东部司(ED)建立了一个充满活力的基础设施，培训了一支敬业的工作人员，并将资源带给了研究界。这项建议的目的是传达教育署的优势和创新，并描述一项计划，通过该计划，已经成功的生物样品采购和分销资源将在未来5年周期内促进和加强生物医学发现。宾夕法尼亚大学(UPenn)作为合作人体组织网络目前的东部分部(ED)提交了这份申请，以继续作为拟议的协作人体组织网络(CHTN)的成人分部。为配合这个目标，我们建议教育署在这个拨款周期内的具体目标如下。1)通过业务创新提高网络对调查人员的价值，以提供多样化的生物样本供应。为了满足CHTN调查人员的专门要求，采用有针对性的来源方法收集标本。2)确保组织、数据和服务的最高质量。使用集成的IT基础设施来监控和促进生物信息库的操作和服务(收集、处理、质量控制、分发和存储)，以保证响应迅速、交互的资源能够适应 新出现的科学趋势。3)通过传播经过验证的、成功的调查员招聘和个性化客户服务品牌，最大限度地发挥资源的影响，确保研究人员对资源的满意度。4)与气候变化网络的其他成员合作，通过加强样本获取、协调各司之间的互操作性以及扩大对创新方法的调查和探索生物信息库科学的新途径，确保获得有效的资源。 教育署建议引入独特和创新的程序方法，以改善网络的实力，以确保分布式生物检疫的质素。

DESCRIPTION (provided by applicant): The core mission of the Cooperative Human Tissue Network has been the distribution of high quality, well-characterized human biospecimens to researchers who study human disease. Over the past 27 years, the current Eastern Division (ED) has built a dynamic infrastructure, has trained a dedicated staff, and has brought the resource to the research community. The purpose of this proposal is to convey the strengths and innovations of the ED and to describe the plan through which an already successful biospecimen procurement and distribution resource will facilitate and enhance biomedical discovery over the next 5 year cycle. The University of Pennsylvania (UPENN) as the current Eastern Division (ED) of the Cooperative Human Tissue Network submits this application to continue as an adult division of the proposed Collaborative Human Tissue Network (CHTN). To support this objective, we propose the following as specific aims of the ED during this grant cycle. 1) To improve the value of the Network to investigators through innovations in operations, in order to provide a diversified supply of biosamples. To fulfill the specialized requests of the CHTN investigators, by using a targeted sourcing approach to specimen collection. 2) To assure the highest possible quality of tissue, data and services. To use an integrated IT infrastructure t monitor and facilitate biorepository operations and services (collection, processing, quality control, distribution, and storage) guaranteeing a responsive, interactive resource that will adapt to emerging scientific trends. 3) To maximize the impact of the resource by disseminating a proven, successful brand of investigator recruitment and personalized customer service, ensuring researcher satisfaction with the resource. 4) To collaborate with other members of the CHTN to ensure an effective resource by enhancing accessibility to samples, harmonizing interoperability between divisions and by expanding investigations into innovative methodologies and exploring new avenues of biorepository sciences. The ED proposes to bring a unique and innovative procedural methodology to improve the strength of the network to guarantee quality of the distributed biospecimens.