COOPERATIVE HUMAN TISSUE NETWORK EASTERN DIVISION

摘要：合作人体组织网络的核心任务是 向研究人员分发高质量、特征良好的人类生物标本 人类疾病。在过去的31年里，目前的东区(ED)建立了一个充满活力的 基础设施，并将资源带给了研究界。这样做的目的是 建议书旨在传达教育署的长处和创新，并透过 已经成功的生物菌素采购和分销资源将促进 并在未来5年周期内加强生物医学发现。宾夕法尼亚大学 (宾夕法尼亚大学)作为合作人体组织网络的现任东部分部(ED) (CHTN)。提交此申请以继续作为拟议网络的成人部门。至 为支持这项目标，我们在这项拨款中提出教育署的具体目标如下 周而复始。1)通过业务创新提高网络对调查人员的价值， 以提供多样化的生物样本供应。来满足专业的要求 CHTN调查人员，通过使用有针对性的来源方法收集标本。2)确保 尽可能高质量的组织、数据和服务。使用集成的IT基础设施来 监控和促进生物信息库的操作和服务(收集、处理、质量 控制、分发和存储)，以保证响应迅速、交互的资源 新出现的科学趋势。3)最大限度地发挥资源的影响，传播 经过验证的成功品牌调查员招聘和个性化客户服务， 确保研究人员对资源的满意度。4)与协会的其他成员合作 CHTN通过提高样本的可及性、协调 各部门之间的互操作性，并通过扩大对创新 方法论和探索生物信息库科学的新途径。 教育署建议引入创新方法，以加强网络的实力，并 保证分布生物菌种的质量。

ABSTRACT: The core mission of the Cooperative Human Tissue Network has been the distribution of high quality, well-characterized human biospecimens to researchers who study human disease. Over the past 31 years, the current Eastern Division (ED) has built a dynamic infrastructure and has brought the resource to the research community. The purpose of this proposal is to convey the strengths and innovations of the ED and to describe the plan through which an already successful biospecimen procurement and distribution resource will facilitate and enhance biomedical discovery over the next 5 year cycle. The University of Pennsylvania (UPENN) as the current Eastern Division (ED) of the Cooperative Human Tissue Network (CHTN). submits this application to continue as an adult division of the proposed network. To support this objective, we present the following as specific aims of the ED during this grant cycle. 1) To improve the value of the Network to investigators through innovations in operations, in order to provide a diversified supply of biosamples. To fulfill the specialized requests of the CHTN investigators, by using a targeted sourcing approach to specimen collection. 2) To assure the highest possible quality of tissue, data and services. To use an integrated IT infrastructure to monitor and facilitate biorepository operations and services (collection, processing, quality control, distribution, and storage) guaranteeing a responsive, interactive resource that will adapt to emerging scientific trends. 3) To maximize the impact of the resource by disseminating a proven, successful brand of investigator recruitment and personalized customer service, ensuring researcher satisfaction with the resource. 4) To collaborate with other members of the CHTN to ensure an effective resource by enhancing accessibility to samples, harmonizing interoperability between divisions and by expanding investigations into innovative methodologies and exploring new avenues of biorepository sciences. The ED proposes to bring a innovative approach to improve the strength of the network and to guarantee quality of the distributed biospecimens.