COLLABORATIVE HUMAN TISSUE NETWORK EASTERN DIVISION

人体组织协作网络东部分部

• 批准号: 9031566
• 负责人: VIRGINIA ANNE LIVOLSI
• 金额: $ 100.43万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-03 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9031566
• 关键词: Adult; Area; Basic Science; Bibliography; Biomedical Research; Collection; Communities; Cooperative Human Tissue Network; Data; Ensure; Fostering; Grant; Health; Human; Industry; Investigation; Lead; Legal patent; Logistics; Medical Research; Methodology; Mission; Monitor; Pennsylvania; Process; Publications; Quality Control; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Science; Services; Technology; Tissues; Training; Training and Infrastructure; Translational Research; Universities; Work; biobank; human disease; human tissue; improved; innovation; interoperability; member; operation; sample collection; satisfaction; success; trend

DESCRIPTION (provided by applicant): The core mission of the Cooperative Human Tissue Network has been the distribution of high quality, well-characterized human biospecimens to researchers who study human disease. Over the past 27 years, the current Eastern Division (ED) has built a dynamic infrastructure, has trained a dedicated staff, and has brought the resource to the research community. The purpose of this proposal is to convey the strengths and innovations of the ED and to describe the plan through which an already successful biospecimen procurement and distribution resource will facilitate and enhance biomedical discovery over the next 5 year cycle. The University of Pennsylvania (UPENN) as the current Eastern Division (ED) of the Cooperative Human Tissue Network submits this application to continue as an adult division of the proposed Collaborative Human Tissue Network (CHTN). To support this objective, we propose the following as specific aims of the ED during this grant cycle. 1) To improve the value of the Network to investigators through innovations in operations, in order to provide a diversified supply of biosamples. To fulfill the specialized requests of the CHTN investigators, by using a targeted sourcing approach to specimen collection. 2) To assure the highest possible quality of tissue, data and services. To use an integrated IT infrastructure t monitor and facilitate biorepository operations and services (collection, processing, quality control, distribution, and storage) guaranteeing a responsive, interactive resource that will adapt to emerging scientific trends. 3) To maximize the impact of the resource by disseminating a proven, successful brand of investigator recruitment and personalized customer service, ensuring researcher satisfaction with the resource. 4) To collaborate with other members of the CHTN to ensure an effective resource by enhancing accessibility to samples, harmonizing interoperability between divisions and by expanding investigations into innovative methodologies and exploring new avenues of biorepository sciences. The ED proposes to bring a unique and innovative procedural methodology to improve the strength of the network to guarantee quality of the distributed biospecimens.

描述（由申请人提供）：合作人体组织网络的核心使命是向研究人类疾病的研究人员分发高质量、特征良好的人体生物标本。在过去的27年里，目前的东部分部（艾德）已经建立了一个充满活力的基础设施，培养了一个专门的工作人员，并带来了资源的研究界。本提案的目的是传达艾德的优势和创新，并描述计划，通过该计划，已经成功的生物标本采购和分配资源将在未来5年周期内促进和加强生物医学发现。宾夕法尼亚大学（UPENN）作为合作人体组织网络的当前东部分部（艾德）提交本申请，以继续作为拟议的合作人体组织网络（CHTN）的成人分部。为支持这一目标，我们建议艾德署在本资助周期内实现以下具体目标。1)通过业务创新提高网络对调查人员的价值，以便提供多样化的生物样本供应。通过有针对性的标本采集方法，满足CHTN调查人员的特殊要求。2)确保组织、数据和服务的最高质量。使用集成的IT基础设施来监控和促进生物储存库的操作和服务（收集、处理、质量控制、分配和储存），以保证响应性强、互动性好的资源， 新兴的科学趋势。3)通过传播经过验证的、成功的研究者招募品牌和个性化的客户服务，最大限度地发挥资源的影响力，确保研究者对资源的满意度。4)与CHTN的其他成员合作，通过提高样品的可访问性，协调各部门之间的互操作性，并通过扩大对创新方法的调查和探索生物保藏科学的新途径，确保有效的资源。 艾德建议采用一种独特的创新程序方法来提高网络的强度，以保证分发的生物标本的质量。