COOPERATIVE HUMAN TISSUE NETWORK EASTERN DIVISION

人体组织合作网络东部分部

• 批准号: 7424218
• 负责人: VIRGINIA ANNE LIVOLSI
• 金额: $ 123.98万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-07 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7424218
• 关键词: Address; Advocate; Area; Awareness; Benign; Binding; Certification; Communities; Controlled Vocabulary; Cooperative Human Tissue Network; Data; Data Analyses; Data Element; Development; Elements; Emerging Technologies; Ensure; Genetic; Human; Immunology; Industry; Informatics; Informed Consent; Intake; Link; Malignant - descriptor; Manuals; Marketing; Methods; Molecular; Molecular Biology; Monitor; National Cancer Institute; Online Systems; Operative Surgical Procedures; Patients; Pennsylvania; Preparation; Procedures; Process; Productivity; Quality Control; Research; Research Personnel; Resources; Rights; Services; Solutions; Specimen; Standards of Weights and Measures; System; Tissue Sample; Tissues; Training Programs; Universities; Work; anticancer research; base; cancer Biomedical Informatics Grid; human tissue; improved; member; patient privacy; programs; satisfaction; tissue processing; tool

{\rtf1\ansi\ansicpg1252\deff0\deflang1033{\fonttbl{\f0\fswiss\fcharset0 Arial;}} {\*\generator Msftedit 5.41.15.1515;}\viewkind4\uc1\pard\f0\fs22 The broad, long-term objective of this application is to continue the participation of the University of\par Pennsylvania as the Eastern Division (ED) of the Cooperative Human Tissue Network (CHTN), which serves\par the public good by stimulating cooperative efforts to collect and distribute human biospecimens and to\par facilitate research utilizing those specimens. These activities are expected to encourage basic and\par developmental studies in many areas of cancer research, including molecular biology, immunology and\par genetics. The ED's aims in support of the CHTN and the scientific community will include providing high\par volumes and diversities of well-characterized malignant, normal, and benign human tissue samples prepared\par to investigator specifications; increasing awareness of the CHTN through marketing efforts and integration of\par patient advocates; working with CHTN members on studies and efforts related to tissue quality; serving on\par the CHTN Coordinating Committee and its subcommittees to improve the network and be bound by its\par decisions; ensuring quality of tissue and services through an integrated Quality Management System (QMS)\par that harmonizes local procedures with the CHTN Manual of Operations (MOO) and National Cancer Institute\par Best Practices for Biospecimen Resources (NCIBP), addressing each step of the process from application\par intake to tissue processing to shipment and billing; offering an integrated informatics program that combines\par participation in CHTN group development activities with sharing of local informatics tools and integration with\par the broader community through cooperation and certification with the cancer Biomedical Informatics Grid\par (caBIG); to provide a web-based solution to allow sharing of QC data and analysis of QC results among all\par CHTN divisions, including the provision of application programming interfaces (API's) as required by caBIG;\par and to protect the rights and privacy of patients whose tissue and/or data may be utilized by severing links to\par the donor in cases for which informed consent is not practicable. Methods will include histological and\par \fs12 ~^\par \fs22 molecular quality control; use of standard operating procedures (SOP's); staff training programs and\par voluntary certifications as available; satisfaction monitoring; and use of controlled vocabularies, common\par data elements, and hierarchical permissions. These approaches are based on ED expertise honed in 20\par years of participation in the CHTN informed by the latest best practices and industry standards.\fs20\par \par }

{\fnSimHei\bord1\shad1\pos（200，288）} {\*\generator Msftedit 5.41.15.1515;}\viewkind4\uc1\pard\f0\fs22本申请的广泛、长期目标是继续参与\par大学 宾夕法尼亚州作为合作人体组织网络（CHTN）的东部分部（艾德），该网络为\par 通过激励合作努力收集和分发人类生物标本并\par来实现公共利益 利用这些标本进行研究。预计这些活动将鼓励基本和\par 癌症研究的许多领域的发展研究，包括分子生物学，免疫学和\par 遗传学艾德支持CHTN和科学界的目标将包括提供高水平的 制备的充分表征的恶性、正常和良性人体组织样本的体积和分布\par 研究者规范;通过营销工作和整合\par 患者倡导者;与CHTN成员合作进行组织质量相关的研究和工作; CHTN协调委员会及其小组委员会，以改善网络，并受其\par 决策;通过综合质量管理体系（QMS）确保组织和服务的质量\par 使当地程序与CHTN操作手册（MOO）和国家癌症研究所协调一致， 生物样本资源最佳实践（NCIBP），解决从应用程序\par 从组织处理到运输和计费;提供一个集成的信息学程序， 参与CHTN小组的开发活动，分享当地信息工具并与\par集成 通过与癌症生物医学信息网格的合作和认证， （caBIG）;提供基于网络的解决方案，允许所有\parr共享QC数据和分析QC结果 CHTN部门，包括按照caBIG的要求提供应用程序编程接口（API）;\par 并保护患者的权利和隐私，患者的组织和/或数据可能通过切断与\par的链接而被利用， 在无法获得知情同意的情况下，捐赠者。方法将包括组织学和\par \fs12 ~^\par 分子质量控制;标准操作程序（SOP）的使用;员工培训计划和 可用的自愿认证;满意度监控;以及使用受控词汇表、通用\par 数据元素和分级权限。这些方法基于20年来磨练的艾德专业知识 多年来参与CHTN，了解最新的最佳实践和行业标准。fs20\par \par }