ORWH: SCOR on Sex and Gender Factors Affecting Women's *

描述(由申请人提供)： 这项建议旨在改善对患有尿失禁和盆腔器官脱垂等优先健康状况的妇女的护理。这些问题是由于妇女在生育中的独特作用而产生的，因此，在男性中发生的频率要低得多。每年有300万妇女接生，11%的妇女因大小便失禁和脱垂而需要手术。对这些疾病所涉及的机制及其对治疗的影响缺乏基本了解，阻碍了进展。我们提议成立SCOR，将现有的5名多学科研究人员联合起来，并增加4名新的研究人员，以加快发展改进治疗和预防所需的新知识。项目1“生物力学”将检验有关盆底结构和功能的基本机制的假说。它将分析盆底组件的机械布置和特性，以及阴道分娩如何损害它们的完整性。项目2，“临床机制”将测试大小便失禁和压力性大小便失禁妇女，以检测与压力性大小便失禁有关的单独和组合部件的独特故障。项目3，“治疗选择”将确定压力性尿失禁妇女出生时肌肉损伤的影响，并根据这些数据建立和测试一个模型，以确定哪些缺陷将预测盆腔肌肉治疗的成功或失败。核心A，行政/人类科目/生物统计核心通过招募受试者、汇编和分析数据以及保护受试者安全来提供项目支持。在核心A中，将组成两个研究小组，讨论1)性别影响和2)基础科学未来，以讨论扩大这项研究提出的问题。核心B，测量和成像将为项目提供技术支持，以及对跨项目收集的2维和3维空间数据进行集成图像分析。这项研究将产生必要的见解，以帮助患有盆底功能障碍的女性。

DESCRIPTION (provided by applicant): This proposal seeks to improve care for the women who suffer the priority health conditions of urinary incontinence and pelvic organ prolapse. These problems arise due to women's unique role in giving birth and, therefore, occur much less often in men. Each year 3 million women deliver babies and 11 % of women need surgery for incontinence and prolapse. A lack of basic understanding of the mechanisms involved in these conditions and their implications for treatment impedes progress. We propose a SCOR to unite 5 existing multidisciplinary researchers and to add 4 new investigators to expedite development of new knowledge needed to improve treatment and prevention. Project 1, "Biomechanics" will test hypotheses concerning basic mechanisms of pelvic floor structure and function. It will analyze the mechanical arrangement and properties of the components of the pelvic floor as well as how vaginal birth damages their integrity. Project 2, "Clinical Mechanisms" will test continent and stress incontinent women to detect the unique failure of component parts that, singularly and in combinations, are associated with stress incontinence. Project 3, "Treatment Selection" will identify the effects of birth induced muscle damage in women with stress incontinence and from these data, build and test a model to determine which defects will predict success or failure of pelvic muscle treatment. Core A, Administrative/Human Subjects/Biostatistics core provides project support by recruiting subjects, compiling and analyzing data and protecting subject safety. In Core A, two study groups will be formed concerning 1) Gender Impact and 2) Basic Sciences Futures to discuss expanding the issues raised by this research. Core B, Measurement & Imaging will provide technical support for the projects along with integrated image analysis for 2 and 3 dimensional spatial data gathered across projects. This research will produce needed insights to help women with pelvic floor dysfunction.