Birth, Muscle Injury and Pelvic Floor Dysfunction

出生、肌肉损伤和盆底功能障碍

• 批准号: 7676165
• 负责人: JOHN O.L. DELANCEY
• 金额: $ 114.4万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-25 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7676165
• 关键词: Birth; Muscle; Injury; Pelvic; Floor

DESCRIPTION (provided by applicant): This proposal seeks to improve care for the women who suffer the priority health conditions of pelvic floor dysfunction; problems that arise due to women's unique role in giving birth. It addresses the sex disparities that exist in these problems. Each year 3 million women deliver babies and 300,000 women need surgery for pelvic floor dysfunction. A lack of basic understanding of the mechanisms of birth-related injury and recovery during reproductive years and mechanisms of prolapse later in life block efforts to prevent damage, improve recovery, or improve treatment. We seek continued support for a broadly interdisciplinary group of researchers from 4 schools and 2 institutes to that has expedited development of new knowledge needed to improve treatment and prevention. Project 1: "Birth Biomechanics" will test hypotheses concerning basic mechanisms of pelvic floor injury during vaginal birth; the single largest factor in causing pelvic floor dysfunction to identify specific situations may increase or decrease injury risk. Project 2: "Injury Recovery" will identify risk factors associated with levator injury, test the hypothesis that these injuries are, in fact, related to vaginal delivery and determine early predictors of eventual recovery. Project 3, "Mechanisms of Posterior Vaginal Prolapse" will use advanced imaging and deformation analysis to test hypotheses concerning the basic disease mechanisms responsible for posterior vaginal wall prolapse, one of the most common and strongly birth-associated pelvic floor dysfunction. Core A: Administrative / Human Subjects / Biostatistics core provides project support by recruiting subjects, compiling and analyzing data and protecting subject safety. In Core A, two study groups will be formed concerning 1) Gender Impact and 2) Basic Science Futures to discuss expanding the issues raised by this research. Core B: Measurement and Imaging core will provide technical support for the projects along with integrated analysis for 2 and 3 dimensional spatial data gathered across projects. This research will produce insights to address the women's health problem of pelvic floor dysfunction

描述（由申请人提供）：该提案旨在改善对患有骨盆底功能障碍优先健康状况的妇女的护理;由于妇女在分娩中的独特作用而产生的问题。它解决了这些问题中存在的性别差异。每年有300万妇女分娩，30万妇女因骨盆底功能障碍需要手术。缺乏对生育相关损伤机制和生育期恢复机制以及生命后期脱垂机制的基本了解，阻碍了预防损伤、改善恢复或改善治疗的努力。我们寻求对来自4所学校和2个研究所的广泛跨学科研究人员小组的持续支持，以加快改善治疗和预防所需的新知识的发展。项目一：“出生生物力学”将测试有关阴道分娩时骨盆底损伤的基本机制的假设;导致骨盆底功能障碍的单一最大因素，以确定特定情况可能会增加或减少损伤风险。项目二：“损伤恢复”将确定与提上睑肌损伤相关的风险因素，测试这些损伤实际上与阴道分娩相关的假设，并确定最终恢复的早期预测因素。项目3，“阴道后壁脱垂的机制”将使用先进的成像和变形分析来测试有关阴道后壁脱垂的基本疾病机制的假设，阴道后壁脱垂是最常见和与分娩密切相关的盆底功能障碍之一。 核心A：管理/人类受试者/生物统计学核心通过招募受试者、编辑和分析数据以及保护受试者安全提供项目支持。在核心A中，将就1）性别影响和2）基础科学未来成立两个研究小组，讨论扩大这项研究提出的问题。核心B：测量和成像核心将为项目提供技术支持，沿着对项目中收集的二维和三维空间数据进行综合分析。这项研究将为解决女性盆底功能障碍的健康问题提供见解