Three-Dimensional Ocular Imaging Using Ultrasound

描述(由申请人提供)：该项目的目标是开发一种能够提供眼前段详细图像的超声成像阵列。该阵列将用于创建解剖图像，用于确定人工晶状体植入物的大小和治疗病理情况，以及用于屈光手术的角膜厚度和地形图。在第一阶段，我们制作了原型换能器元件，并证明这些元件具有足够的灵敏度来检测体外牛眼的角膜前、后表面和Bowman膜。在第二阶段，我们计划制造一个完整的二维成像阵列，并在眼库提供的声学模型、兔眼和人眼上测试该阵列。康奈尔大学威尔医学院的临床合作者将对动物和人类的眼睛进行测试。我们还将与我们的商业化合作伙伴合作，将我们的阵列集成到他们的眼睛成像系统中。

DESCRIPTION (provided by applicant): The goal of this project is development of an ultrasonic imaging array capable of providing detailed images of the anterior segment of the eye. The array will be used to create anatomic images used for sizing of intraocular lens implants and treating pathological conditions, as well as pachymetric and topographic maps used in refractive surgery. During Phase I, we fabricated prototype transducer elements and demonstrated that the elements had sufficient sensitivity to detect the anterior and posterior corneal surfaces and Bowman's membrane in an ex vivo bovine eye. In Phase II, we plan to fabricate a complete two-dimensional imaging array and test the array on acoustic phantoms, rabbit eyes, and human eyes provided by the eye bank. Testing on animal and human eyes will be conducted by our clinical collaborators at the Weill Medical College of Cornell University. We will also work with our commercialization partner to integrate our array into their ocular imaging system.