A Vervet Monkey (Cercopithecus Aethiops) Genetic Map

黑长尾猴（Cercopithecus Aethiops）遗传图谱

• 批准号: 6470879
• 负责人: NELSON B. FREIMER
• 金额: $ 41.02万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6470879
• 关键词: Cercopithecidae; artificial chromosomes; behavioral /social science research tag; behavioral genetics; ethology; fluorescent in situ hybridization; gene expression; genetic library; genetic mapping; genetic markers; genetic polymorphism; genome; genotype; linkage mapping; maternal behavior; phenotype; polymerase chain reaction; population genetics; quantitative trait loci; sex behavior; social behavior

DESCRIPTION (provided by applicant): This is a proposal to develop an integrated genetic resource for investigations of complex traits in the vervet monkey (Cercopithecus aethiops), also known as the African Green monkey. Studies of non-human primates are invaluable for furthering understanding of a wide range of human diseases and traits, especially complex behaviors. The utility of such studies derives from the fact that humans are much more similar to other primates than they are to commonly used mammalian model organisms such as the mouse. The vervet is widely used in biomedical research, particularly for investigation of complex behavioral traits. A captive population at the UCLA-VA Vervet Monkey Research Colony (VMRC) contains a large number of normally reared animals in an extended six-generation pedigree, with most relationships verified by DNA marker typing. Sub-sections of this pedigree will be genotyped to construct two related genetic maps. The first map consists of about 600 human microsatellite markers that cover most of the human genome, and that have already been shown to be polymorphic in vervets under standard genotyping conditions. The relative location of these markers in the vervet genome will be confirmed by multipoint linkage analyses and fluorescence in situ hybridization (FISH). Additional markers will be chosen to minimize the number of large gaps (greater than 15 cM) in the genetic map. A complementary map will consist of up to 2000 single nucleotide polymorphisms (SNPs) drawn from the 3? end of genes. These maps will be used by the scientific community for genetic mapping studies of complex traits in the VMRC pedigree and in vervet populations sited at several other locations. A large insert clone library that we will construct will anchor the genetic maps to the vervet genome and will facilitate the identification of genes that are implicated in predisposition to particular vervet traits. This library will also be useful for investigators who wish to study use of a vervet model to study particular candidate genes identified from investigations of humans.

描述（由申请人提供）：这是一份开发一种