CORE--BIOENGINEERING AND BASIC SCIENCE

描述：（申请人提供）工程和基础的目标 科学核心是促进老年学和老年医学研究， 临床医生、临床研究人员、基础科学家和工程师， 通过为教师和学员提供尖端技术， 老龄化司。这个核心将促进新发现的发展 以及诊断和治疗方面的改进， 老年人。具体而言，该核心旨在使工程和 细胞和分子生物学的研究机会一般访问， 通过提供以下服务，为老龄问题司的成员提供服务： 步态评估服务贷款设备的步态评估，以病人为导向 在步态实验室外的环境中。2)非线性分析 在分析方法的应用方面提供专家帮助 从统计物理学和“混沌”理论衍生到（病理生理学）的研究 时间序列和空间测量。3)生物数据 采购服务贷款传感器，放大器，和录音机， 监测生理信号（例如，ECG、血压） 研究衰老和与年龄有关的疾病的实验。4)生物 信号处理服务数字化，显示和分析生物 信号. 5)图像采集服务提供访问研究级 荧光视频显微镜和串联扫描共聚焦显微镜。6)一个 图像处理和判读处进行数字图像处理 的图像。7)转基因动物设计服务提供技术援助 关于适当DNA构建体的制备和/或 特定的基因突变8)基因组扫描服务协助调查人员 通过鉴定那些基因组序列和DNA标记物， 可能与晚年的流行病有关，如心脏病， 疾病、癌症和神经退行性疾病。9)的基因表达谱 服务提供了高吞吐量技术， 基因表达谱特征的老化和各种年龄相关的 疾病状态。10)“老有所养”的未来之家设计服务 帮助开发一个特别设计的生活空间， 最大限度地提高老年人的独立性， 成功地在社区。

Description: (provided by the applicant) The goal of the Engineering and Basic Science Core is to promote gerontologic and geriatric research by bringing together clinicians, clinical researchers, basic scientists and engineers and by offering cutting-edge technology to the faculty and trainees of the Division on Aging. This core will foster the development of new discoveries and improvements in diagnosis and therapy that will enhance the independence of older persons. Specifically, this core is designed to make engineering and cell and molecular biology research opportunities generally accessible to members of the Division on Aging by providing the following services: 1) A Gait Assessment Service loans equipment for the assessment of gait in patient-oriented settings outside of the gait laboratory. 2) A Nonlinear Analysis Service provides expert assistance in the application of analysis methods derived from statistical physics and "chaos" theory to the study of (patho-physiologic time series and spatial measurements. 3) A Biological Data Acquisition Service loans transducers, amplifiers, and recorders for the monitoring of physiological signals (e.g., ECG, blood pressure) during experiments of the study of aging and age-related disease. 4) A Biological Signal Processing Service digitizes, displays, and analyzes biological signals. 5) An Image Acquisition Service provides access to a research grade fluorescence video microscope and tandem scanning confocal microscopes. 6) An Image Processing and Interpretation Service performs digital image processing of images. 7) A Transgenic Animal Design Service provides technical assistance regarding preparation of the appropriate DNA construct and/or creation of specific gene mutations. 8) A Genome Scanning Service assists the investigator with the identification of those genomic sequences and DNA marker panels that may be associated with the prevalent diseases of late life, such as heart disease, cancer, and neurodegenerative diseases. 9) A Gene Expression Profile Service provides access to high throughput technology for the performance of gene expression profile characterization of aging and various age-associated disease states. 10) An "Aging In Place" Home of the Future Design Service assists in the development of a living-space that is especially designed to maximize the independence of older persons and extend their ability to live successfully in the community.