Epigenetic regulation of CD8+ T cell function and memory.

CD8 T 细胞功能和记忆的表观遗传调控。

• 批准号: nhmrc : 1003131
• 负责人: Prof Stephen Turner
• 金额: $ 38.55万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-regulation-cd8-function-memory/108901
• 关键词: Epigenetic; regulation; CD8+; cell; function

Upon virus infection, a subset of white blood cells, called killer T cells, are recruited to fight the infection. This proposal aims to examine molecular changes that occur within killer T cells and impart their specific function. We also aim to understand how killer T cells are _programmed� as they establish immunological memory. This proposal will provide insights important for the design and improvement of vaccine strategies to fight pathogens such as influenza, HIV and even tumors.

病毒感染后，白细胞的一个子集，称为杀伤T细胞，被招募来对抗感染。这一提议旨在研究发生在杀伤T细胞内的分子变化，并赋予它们特定的功能。我们还致力于了解杀伤性T细胞在建立免疫记忆时是如何被编程的。这一建议将为设计和改进疫苗战略以对抗流感、艾滋病毒甚至肿瘤等病原体提供重要见解。