The role of Kdm1a in epigenetic regulation of virus-specific T cell differentiation.

Kdm1a 在病毒特异性 T 细胞分化的表观遗传调控中的作用。

• 批准号: nhmrc : 1065628
• 负责人: Prof Stephen Turner
• 金额: $ 34.07万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-kdm1a-epigenetic-cell-differentiation/455184
• 关键词: role; Kdm1a; epigenetic; regulation; virus

Recovery from infection, or vaccination, results in the establishment of protective immunity that persists for the life of an individual. Unfortunately, our understanding of how protective immunity is established and maintained after infection or vaccination is lacking. This proposal will determine whether specific enzymes involved in rewriting the genetic blueprint are key for establishing and maintaining this protective capacity. Understanding these mechanisms has implications for vaccination and improved immunotherapy strategies for cancer.

从感染中恢复或接种疫苗，导致建立保护性免疫，持续个体的生命。不幸的是，我们对感染或接种疫苗后如何建立和维持保护性免疫的理解是缺乏的。这项提议将确定参与重写遗传蓝图的特定酶是否是建立和维持这种保护能力的关键。了解这些机制对疫苗接种和改善癌症免疫治疗策略具有重要意义。