The epigenetic blueprint for T cell differentiation: a genomic view

T 细胞分化的表观遗传蓝图：基因组观点

• 批准号: DP140101579
• 负责人: Prof Stephen Turner
• 金额: $ 28.9万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140101579
• 关键词: epigenetic; blueprint; cell; differentiation; genomic

A cardinal feature of adaptive immune cell activation is the initiation of a program of differentiation that results in acquisition and long term maintenance of lineage-speci?c effector function. This proposal aims to map and dissect genome wide molecular changes that occur at different stages of immune cell differentiation and identify key factors that regulating these changes. It is expected that distinct genomic signatures, and the mechanisms indicative of effective immune cell differentiation will be identified. This proposal will provide insights into key mechanisms that result in reprogramming of immune cell function and memory and have implications for understanding general cellular differentiation.

获得性免疫细胞激活的一个基本特征是启动分化程序，导致获得和长期维持谱系特异性效应功能。这项建议旨在绘制和剖析发生在免疫细胞分化不同阶段的全基因组分子变化，并确定调节这些变化的关键因素。预计将识别出不同的基因组特征，以及表明有效免疫细胞分化的机制。这一提议将提供对导致免疫细胞功能和记忆重新编程的关键机制的见解，并对理解一般细胞分化具有意义。