CORE-- CLINICAL

核心——临床

• 批准号: 6563290
• 负责人: DAVID ALAN BENNETT
• 金额: $ 17.85万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6563290
• 关键词: African American; Alzheimer's disease; Hispanic Americans; behavioral /social science research tag; biomedical facility; body physical activity; brain disorder diagnosis; clinical research; computer data analysis; diagnosis design /evaluation; disease /disorder classification; human subject; interview; longitudinal human study; medical outreach /case finding; nervous system disorder epidemiology; neuropathology; neuropsychological tests; neuropsychology; patient /disease registry; postmortem; psychometrics

DESCRIPTION (provided by applicant): The goal of the Clinical Core is to facilitate high quality clinical, neuropsychological, epidemiological and neuropathological research regarding Alzheimer's disease. Three considerations influenced the design of the proposed Core: the expertise of investigators at Rush, the establishment of a Memory Assessment Clinic at Cook County Hospital, and the success of the Religious Orders Study Core. These considerations led to a design that will recruit and follow very large numbers of cases and controls for clinical studies but a relatively small group for neuropathologic studies, and will emphasize enrollment of African American and Hispanic minorities. The Core proposes to perform uniform structured baseline evaluations and follow 1,750 persons with dementia who agree to a brief annual informant interview, 150 persons who agree to a detailed annual clinical evaluation and brain donation at death, and 250 controls who agree to an annual interview. This approach will provide investigators using Core resources a large pool of subjects who are potentially eligible for externally funded studies. This approach will allow the Clinical Core to continue to build on its record of success. During the past project period, more than 1,600 persons enrolled in the Core. Follow-up interviews were performed on more than 85%. Almost 500 persons participated in one or more of 14 externally funded clinical projects. In addition, the overall autopsy rate in the Core exceeds 80% (265 autopsies of 322 deaths). Brain tissue from almost 150 persons were used in externally funded studies. Core personnel facilitated 22 other funded projects. While minority enrollment in the Core and in studies using subjects from the Core are both in excess of 15%, the Memory Assessment Clinic at Cook County should greatly facilitate enrollment of additional minorities.

描述（由申请人提供）： 临床核心的目的是促进高质量的临床 关于神经心理学，流行病学和神经病理学研究 阿尔茨海默氏病。三个考虑影响了设计 拟议中的核心：Rush的调查人员的专业知识，建立 库克县医院的记忆评估诊所， 宗教秩序研究核心。这些考虑导致了一个设计 招募并遵循大量临床病例和对照 研究只是一个相对较小的神经病理学研究的组，将 强调入学非裔美国人和西班牙裔少数民族。核心 提议进行统一的结构化基线评估并遵循1,750 痴呆症患者同意简短的年度线人面试，150 同意详细的年度临床评估和大脑捐赠的人 死亡时，同意年度面试的250个控件。这种方法 将使用核心资源为调查人员提供大量主题 有可能有资格获得外部资助的研究。 这种方法将使临床核心能够继续在其记录下建立 成功。在过去的项目期间，有1,600多人入学 在核心。对85％以上的后续采访进行了后续采访。将近500 参加了14个外部资助的临床项目中的一个或多个人。 此外，核心的总体尸检率超过80％（265个尸检 322人死亡）。外部使用了近150人的脑组织 资助研究。核心人员促进了其他22个资助的项目。尽管 使用核心的受试者的核心和研究中的少数群体入学 库克县的记忆评估诊所都超过15％ 极大地促进了其他少数民族的入学率。