BRAIN: MRI W/ INTERMOLECULAR ZERO QUANTUM COHERENCES

大脑：具有分子间零量子相干性的 MRI

• 批准号: 6657657
• 负责人: RAHIM R RIZI
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6657657
• 关键词: biomedical resource; human tissue

To implement and evaluate a noninvasive magnetic resonance method of pulmonary perfusion imaging in healthy volunteers. A respiratory-triggered. three-dimensional gradient-echo pulse sequence is used with an extremely short echo-time (TE) to allow observation of the lung parenchyma without the need for breatholding. Continuous magnetic labeling of the pulmonary blood flow is effected by flow-induced adiabatic fast passage inversion. Estimated correction for off-resonance effects due to the labeling pulse is performed. Images acquired under conditions of arterial spin labeling are subtracted from control images to yield a three-dimensional image of the signal change induced by arterial labeling. Data are acquired before and after exercise in a subset of subjects. Uniform signal intensity changes are observed to the level of the parietal pleura in all subjects. This method provides high-resolution three-dimensional images which reflect regional pulmonary blood flow and volume without the need for breatholding. We anticipate that it will be useful in the evaluation of patients with pulmonary disease, especially in the diagnosis of pulmonary thromboembolic disease.

实施和评价一种无创磁共振方法 肺灌注成像的研究。 一个自动触发的。 三维梯度回波 脉冲序列与极短的回波时间（TE）一起使用， 无需屏息即可观察肺实质。 肺血流的连续磁标记是有效的 通过流动诱导的绝热快速通道反转。 估计 由于标记脉冲引起的非共振效应的校正是 执行。 在动脉自旋标记条件下采集的图像 以产生三维图像 动脉标记引起的信号变化。 获取数据 在一个受试者子集中运动前后。 统一信号 强度变化观察到壁层胸膜的水平， 所有科目。 这种方法提供了高分辨率的三维图像 其反映了局部肺血流量和容量，而没有 呼吸的需要。 我们预计，这将有助于 评估肺部疾病患者，尤其是 诊断肺血栓栓塞性疾病。