BRAIN: MRI W/ INTERMOLECULAR ZERO QUANTUM COHERENCES

实施和评估一种无创磁共振方法 健康志愿者的肺血流灌注成像。 一种呼吸触发的。三维梯度回波 脉冲序列与极短的回声时间(TE)一起使用以允许 无需屏气即可观察肺实质。 实现了对肺血流的连续磁性标记 通过流动诱导的绝热快速通道反演。估计 对由标记脉冲引起的非共振效应的校正是 已执行。动脉自旋标记条件下采集的图像 从对照图像中减去以产生三维图像 动脉标记物引起的信号变化。获取数据 在受试者的子集中，在锻炼前后。均匀信号 观察到顶层胸膜水平的密度变化。 所有受试者。 该方法提供了高分辨率的三维图像 反映区域肺血流量和容量，而不是 需要屏住呼吸。我们预计，它将在 对肺部疾病患者的评估，特别是在 肺血栓栓塞性疾病的诊断。

To implement and evaluate a noninvasive magnetic resonance method of pulmonary perfusion imaging in healthy volunteers. A respiratory-triggered. three-dimensional gradient-echo pulse sequence is used with an extremely short echo-time (TE) to allow observation of the lung parenchyma without the need for breatholding. Continuous magnetic labeling of the pulmonary blood flow is effected by flow-induced adiabatic fast passage inversion. Estimated correction for off-resonance effects due to the labeling pulse is performed. Images acquired under conditions of arterial spin labeling are subtracted from control images to yield a three-dimensional image of the signal change induced by arterial labeling. Data are acquired before and after exercise in a subset of subjects. Uniform signal intensity changes are observed to the level of the parietal pleura in all subjects. This method provides high-resolution three-dimensional images which reflect regional pulmonary blood flow and volume without the need for breatholding. We anticipate that it will be useful in the evaluation of patients with pulmonary disease, especially in the diagnosis of pulmonary thromboembolic disease.