HETEROCYCLE-METAL PI COMPLEXES IN ORGANIC SYNTHESIS

有机合成中的杂环金属PI配合物

• 批准号: 3302039
• 负责人: LANNY S LIEBESKIND
• 金额: $ 21.96万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-12-01 至 1996-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3302039
• 关键词: antibiotics; chemical reaction; chemical synthesis; heterocyclic compounds; metal complex; stereoisomer

New and general strategies for the enantio- and regiospecific construction of molecules of medicinal interest (antivirals, antibiotics, antitumor agents, etc.) are important to the overall mission of the NIH. The development of new methods for the regio- and enantiospecific synthesis of highly substituted heterocycles (dihydro- and tetrahydropyrans, furans, piperidines and pyrroles) is described. This proposal will emphasize the use in organic synthesis of various substituted heterocycle-metal pi-complexes (eta4-, eta2-, eta3-2H-furan and pyrrole; eta5-, eta3-, eta4-2H-pyran and pyridine) derived from carbohydrate precursors to provide enantiomerically pure derivatives of the above mentioned classes of compounds. Successful achievement of this new strategy would introduce a novel method for the synthesis of important classes of heterocyclic organic compounds with demonstrated biological activity in a wide variety of assays (antiviral, antibiotic, etc.).

针对具体地区和具体区域的新的和总的战略