HETEROCYCLE-METAL PI-COMPLEXES IN ORGANIC SYNTHESIS

有机合成中的杂环金属 PI 配合物

• 批准号: 3302040
• 负责人: LANNY S LIEBESKIND
• 金额: $ 11.92万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-12-01 至 1992-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3302040
• 关键词: antibiotics; antiviral agents; deoxyribose; drug design /synthesis /production; furans; heterocyclic compounds; metal complex; organic chemicals; piperidine; pyrans; pyrroles; pyrrolidines; ribose; saturated /unsaturated bonds; stereochemistry

The development of new methods for the regio- and stereospecific synthesis of highly substituted heterocycles (dihydro- and tetrahydro- pyrans, furans, piperidines and pyrroles) is proposed. Successful achievement of the proposed chemistry should provide a novel strategy for the synthesis of general classes of organic molecules with demonstrated biologically activity (antiviral, antibiotics, etc.). Unsaturated heterocycles (furan, pyranyl, pyrrole, pyridinyl) will be pi- complexed to transition metal moieties to provide cationic eta4-furan, eta5-pyranyl, eta4-pyrrole, and eta5-pyridinyl species that will be reacted sequentially with nucleophiles and electrophiles in order to prepare highly derivatized oxygen and nitrogen heterocycles in a regio- and stereodefined manner. The metal template in the pi-complexes serves a number of useful roles. It will be used to 1) stabilize otherwise unstable species 2) active unsaturated heterocycles for reaction with nucleophiles, and 3) control the stereochemistry and regiochemistry of the introduction of various organic units to the heterocycle core.

区域特异性和立体特异性合成新方法的发展