HETEROCYCLE-METAL PI COMPLEXES IN ORGANIC SYNTHESIS

对映体和区域特异性的新的和一般的策略 构建具有医学意义的分子（抗病毒药，抗生素， 抗肿瘤剂等）对NIH的整体使命很重要。 区域特异性和对映体特异性新方法的发展 高度取代的杂环（二氢-和 四氢吡喃、呋喃、哌啶和吡咯）。 这 建议将强调在有机合成中使用各种 取代的杂环-金属π-络合物（η 4-，η 2-，η 3 - 2 H-呋喃 和吡咯; η 5-、η 3-、η 4 - 2 H-吡喃和吡啶）， 碳水化合物前体，以提供对映体纯的 上述化合物的种类。 成功实现这一目标 新的策略将引入一种新的合成方法， 杂环有机化合物的重要类别， 在多种测定（抗病毒，抗生素， 等）。

New and general strategies for the enantio- and regiospecific construction of molecules of medicinal interest (antivirals, antibiotics, antitumor agents, etc.) are important to the overall mission of the NIH. The development of new methods for the regio- and enantiospecific synthesis of highly substituted heterocycles (dihydro- and tetrahydropyrans, furans, piperidines and pyrroles) is described. This proposal will emphasize the use in organic synthesis of various substituted heterocycle-metal pi-complexes (eta4-, eta2-, eta3-2H-furan and pyrrole; eta5-, eta3-, eta4-2H-pyran and pyridine) derived from carbohydrate precursors to provide enantiomerically pure derivatives of the above mentioned classes of compounds. Successful achievement of this new strategy would introduce a novel method for the synthesis of important classes of heterocyclic organic compounds with demonstrated biological activity in a wide variety of assays (antiviral, antibiotic, etc.).